Multicentric reticulohistiocytosis without arthritis successfully treated with systemic corticosteroids - A case report and literature review

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Abstract

A 46-year-old male presented with a 2-month history of multiple red papules on the cheeks and extremities without mucosal involvement or arthritis. There were only some lesions on the dorsal hands without periungual involvement. Biopsy of a skin lesion showed a dermal infiltrate consisting of mononuclear and multinucleated histiocytes with granular "ground glass"-like cytoplasm. These histiocytes were CD68-positive, and S-100 protein and CD30 negative in immunohistochemical studies. The diagnosis of multicentric reticulohistiocytosis without arthritis was made. Laboratory data were within normal limits except mild hypercholesterolemia and hypertriglyceridemia. A survey for internal malignancy showed negative results. The skin lesions responded to prednisolone 0.5 mg/kg daily. The dose was tapered gradually; the cutaneous lesions almost completely resolved after 15 weeks of treatment. Whether multicentric reticulohistiocytosis without arthritis is a subtype with better response to treatment remains to be confirmed by more clinical observation, but systemic corticosteroids may be tried first before starting other immunosuppressive or cytotoxic drugs.

Original languageEnglish
Pages (from-to)119-122
Number of pages4
JournalDermatologica Sinica
Volume24
Issue number2
Publication statusPublished - 2006 Jun 1

All Science Journal Classification (ASJC) codes

  • Dermatology

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