Multimodal exercise ameliorates exercise responses and body composition in head and neck cancer patients receiving chemotherapy

Chia-Jui Yen, Ching-Hsia Hung, Chung Lan Kao, Wei Ming Tsai, Shih-Hung Chan, Hui Ching Cheng, Wan Ting Jheng, Yan Jhen Lu, Kun-Ling Tsai

Research output: Contribution to journalArticle

Abstract

Background: Studies have found that many chemotherapy drugs will produce multiple side effects and complications in cancer patients, especially in the case of the cardiovascular disease. This study was intended to investigate whether the exercise training intervention could improve the body composition and exercise responses of patients with head and neck (H&N) cancer who are receiving chemotherapy. Methods: This is a randomized controlled trial. Eighty-four H&N patients were assigned to sedentary group or exercise group. The data were collected pretraining and posttraining, where the body composition, heart rate (HR), blood pressure (BP), rate-pressure product (RPP), and exercise capacity were measured. Results: Our data reported that body weight and body mass index were decreased after 8 weeks of chemotherapy in the sedentary group but not in the exercise group. The decreased visceral fat and the increased skeletal muscle rate had been found in the exercise group after 8 weeks of training. In addition, in the exercise group, the HR, HR recovery, BP, BP recovery, RPP, and minutes walking distance were better than the sedentary group. Results from this study suggested exercise training significantly improved exercise responses and body composition. Conclusion: These findings suggested that exercise can help to promote cardiopulmonary fitness and exercise capacity for H&N cancer patients undergoing chemotherapy.

Original languageEnglish
JournalSupportive Care in Cancer
DOIs
Publication statusPublished - 2019 Jan 1

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Head and Neck Neoplasms
Body Composition
Exercise
Drug Therapy
Heart Rate
Blood Pressure
Pressure
Neoplasms
Intra-Abdominal Fat
Walking
Skeletal Muscle
Body Mass Index
Neck
Cardiovascular Diseases
Randomized Controlled Trials
Head
Body Weight

All Science Journal Classification (ASJC) codes

  • Oncology

Cite this

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title = "Multimodal exercise ameliorates exercise responses and body composition in head and neck cancer patients receiving chemotherapy",
abstract = "Background: Studies have found that many chemotherapy drugs will produce multiple side effects and complications in cancer patients, especially in the case of the cardiovascular disease. This study was intended to investigate whether the exercise training intervention could improve the body composition and exercise responses of patients with head and neck (H&N) cancer who are receiving chemotherapy. Methods: This is a randomized controlled trial. Eighty-four H&N patients were assigned to sedentary group or exercise group. The data were collected pretraining and posttraining, where the body composition, heart rate (HR), blood pressure (BP), rate-pressure product (RPP), and exercise capacity were measured. Results: Our data reported that body weight and body mass index were decreased after 8 weeks of chemotherapy in the sedentary group but not in the exercise group. The decreased visceral fat and the increased skeletal muscle rate had been found in the exercise group after 8 weeks of training. In addition, in the exercise group, the HR, HR recovery, BP, BP recovery, RPP, and minutes walking distance were better than the sedentary group. Results from this study suggested exercise training significantly improved exercise responses and body composition. Conclusion: These findings suggested that exercise can help to promote cardiopulmonary fitness and exercise capacity for H&N cancer patients undergoing chemotherapy.",
author = "Chia-Jui Yen and Ching-Hsia Hung and Kao, {Chung Lan} and Tsai, {Wei Ming} and Shih-Hung Chan and Cheng, {Hui Ching} and Jheng, {Wan Ting} and Lu, {Yan Jhen} and Kun-Ling Tsai",
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Multimodal exercise ameliorates exercise responses and body composition in head and neck cancer patients receiving chemotherapy. / Yen, Chia-Jui; Hung, Ching-Hsia; Kao, Chung Lan; Tsai, Wei Ming; Chan, Shih-Hung; Cheng, Hui Ching; Jheng, Wan Ting; Lu, Yan Jhen; Tsai, Kun-Ling.

In: Supportive Care in Cancer, 01.01.2019.

Research output: Contribution to journalArticle

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AU - Yen, Chia-Jui

AU - Hung, Ching-Hsia

AU - Kao, Chung Lan

AU - Tsai, Wei Ming

AU - Chan, Shih-Hung

AU - Cheng, Hui Ching

AU - Jheng, Wan Ting

AU - Lu, Yan Jhen

AU - Tsai, Kun-Ling

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Studies have found that many chemotherapy drugs will produce multiple side effects and complications in cancer patients, especially in the case of the cardiovascular disease. This study was intended to investigate whether the exercise training intervention could improve the body composition and exercise responses of patients with head and neck (H&N) cancer who are receiving chemotherapy. Methods: This is a randomized controlled trial. Eighty-four H&N patients were assigned to sedentary group or exercise group. The data were collected pretraining and posttraining, where the body composition, heart rate (HR), blood pressure (BP), rate-pressure product (RPP), and exercise capacity were measured. Results: Our data reported that body weight and body mass index were decreased after 8 weeks of chemotherapy in the sedentary group but not in the exercise group. The decreased visceral fat and the increased skeletal muscle rate had been found in the exercise group after 8 weeks of training. In addition, in the exercise group, the HR, HR recovery, BP, BP recovery, RPP, and minutes walking distance were better than the sedentary group. Results from this study suggested exercise training significantly improved exercise responses and body composition. Conclusion: These findings suggested that exercise can help to promote cardiopulmonary fitness and exercise capacity for H&N cancer patients undergoing chemotherapy.

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