TY - JOUR
T1 - Multiscale approximate entropy for gait analysis in patients with neurodegenerative diseases
AU - Liu, An Bang
AU - Lin, Che Wei
N1 - Funding Information:
Department of Neurology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University, Hualien 97002, Taiwan; [email protected] Department of Biomedical Engineering and Medical Device Innovation Center, National Cheng Kung University, Tainan 70101, Taiwan Correspondence: [email protected]
Funding Information:
We would like to thank Jen-Hung Wang, Epidemiology and Biostatistics Consulting Center, Hualien Tzu Chi Hospital, for help with the statistical analysis and interpretations, and Hsin-Ru Liu Department of Medical Research, Hualien Tzu Chi Hospital, for help in preparation and graphing in this manuscript. This study was partly sponsored by research grants from Hualien Tzu Chi General Hospital and Buddhist Tzuchi Medical Foundation Academic Advancement, Hualien, Taiwan (Grant No. TCRD 108-51 and TCMF-A 108-01-10, TCMF-P 108-08), National Cheng Kung University-Show Chwan Health Care System R&D Project, under Grant B108-F301 (Grant No. NCKUSCMH 10801), Ministry of Science and Technology, Taiwan, R.O.C. (Grant No. MOST 108-2628-006-003-MY3).
Funding Information:
Funding: This study was partly sponsored by research grants from Hualien Tzu Chi General Hospital and Buddhist Tzuchi Medical Foundation Academic Advancement, Hualien, Taiwan (Grant No. TCRD 108-51 and TCMF-A 108-01-10, TCMF-P 108-08), National Cheng Kung University-Show Chwan Health Care System R&D Project, under Grant B108-F301 (Grant No. NCKUSCMH 10801), Ministry of Science and Technology, Taiwan, R.O.C. (Grant No. MOST 108-2628-006-003-MY3).
Publisher Copyright:
© 2019 by the authors.
PY - 2019/10/1
Y1 - 2019/10/1
N2 - Neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Parkinson's diseases (PD), and Huntington's disease (HD) are not rare neurological diseases. They affect different neurological systems and present various characteristic gait abnormalities. We retrieved gait signals of the right and left feet from a public domain on the Physionet. There were 13 patients with ALS, 15 patients with PD, 20 patients with HD and 16 healthy controls (HC).We used multiscale approximate entropy (MAE) to analyze ground reaction force on both feet. Our study shows that MAE increases with scales in all tested subjects. The group HD has the highest MAE and group ALS has the lowest MAE.We can differentiate ALS from HC by MAE, while scale factors > 10 in the left foot. There are few significant differences of MAE between the HC and HD.We found a good correlation of MAE between both feet in group ALS. In conclusion, our results indicate that MAE analysis of gait signals can be used for diagnosis and long-term assessment for ALS and probably HD. Similarity of MAE between both feet can also be a diagnostic marker for ALS.
AB - Neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Parkinson's diseases (PD), and Huntington's disease (HD) are not rare neurological diseases. They affect different neurological systems and present various characteristic gait abnormalities. We retrieved gait signals of the right and left feet from a public domain on the Physionet. There were 13 patients with ALS, 15 patients with PD, 20 patients with HD and 16 healthy controls (HC).We used multiscale approximate entropy (MAE) to analyze ground reaction force on both feet. Our study shows that MAE increases with scales in all tested subjects. The group HD has the highest MAE and group ALS has the lowest MAE.We can differentiate ALS from HC by MAE, while scale factors > 10 in the left foot. There are few significant differences of MAE between the HC and HD.We found a good correlation of MAE between both feet in group ALS. In conclusion, our results indicate that MAE analysis of gait signals can be used for diagnosis and long-term assessment for ALS and probably HD. Similarity of MAE between both feet can also be a diagnostic marker for ALS.
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U2 - 10.3390/e21100934
DO - 10.3390/e21100934
M3 - Article
AN - SCOPUS:85074006950
SN - 1099-4300
VL - 21
JO - Entropy
JF - Entropy
IS - 10
M1 - 934
ER -