Musculoskeletal changes in children prenatally exposed to polychlorinated biphenyls and related compounds (yucheng children)

Y. L. Guo, C. J. Lin, W. J. Yao, J. J. Ryan, C. C. Hsu

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Fiftyfive YuCheng (oildisease) children born between 1978 and 1985 to mothers who ate PCBcontaminated rice oil in 1978-1979 were studied and compared to age and sex matched control subjects in 1991. The children’s growth profiles, bone mineral density and soft tissue composition, joint laxity, and serum parathyroid hormone, vitamin D, calcium, alkaline phosphatase, and phosphate were compared. The YuCheng children were 3.1 cm (p <.05) smaller and had less total lean mass and soft tissue mass as compared to the matched control subjects. All other parameters studied were similar in both groups. The shorter height and decreased total lean mass and soft tissue content were only seen in the YuCheng children who were the first born after the ingestion, but not in subsequent children. This was most likely due to decreased body burdens of the PCBs and related contaminants over time in the mothers.

Original languageEnglish
Pages (from-to)83-93
Number of pages11
JournalJournal of Toxicology and Environmental Health
Volume41
Issue number1
DOIs
Publication statusPublished - 1994 Jan 1

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pollution

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