Mutation analysis of x-linked hypohidrotic ectodermal dysplasia in a Taiwanese family

X-linked hypohidrotic ectodermal dysplasia (XLHED, OMOM 305100) is the most common from among the ectodermal dysplasia, a rare group of hereditary diseases characterized by abnormal development of eccrine sweat glands, hair and teeth. Heterozygous carriers of XLHED often manifest minor or moderate degrees of hypotrichosis, hypodontia, and hypohidrosis. ED1, the gene involved in XLHED, encodes ectodysplasin A, a new member of the tumor necrosis factor family. The majority of mutations in XLHED are missense mutations, but one-fifth are insertion/deletions. In this report, we describe the mutation analysis of a Taiwanese pedigree with XLHED. A 35-bp deletion in exon 5 of the ED1 gene was found in th 3 affected males and in 5 female carriers. Mutation analysis in families with XLHED allows for genetic counseling, prenatal diagnosis, and confirmation of carrier status.