N-Acetyl-cysteine against noise-induced temporary threshold shift in male workers

Cheng-Yu Lin, Jiunn-Liang Wu, Tung Sheng Shih, Peng-Chi Tsai, Yih Min Sun, Mi-Chia Ma, Yueliang L. Guo

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Previous animal studies showed protective effects of antioxidant medicines against noise-induced hearing loss (NIHL). It is unclear whether antioxidants would protect humans from NIHL. We conducted a study to determine whether N-Acetyl-cysteine (NAC) protected men against noise-induced temporary threshold shift (TTS), and whether subgroups with genetic polymorphisms of glutathione S-transferase (GST) T1 and M1 responded to NAC differently. In this prospective, double-blind, crossover study, 53 male workers were randomly assigned to receive either NAC (1200 mg/day, 14 days) during the first period and placebo during the second period, or placebo during the first period and NAC during the second period. Dosing periods were separated by a washout period of 2 weeks. The hearing threshold changes were determined before and after each dosing period. Pre-shift hearing threshold for high frequencies was 19.1 dB. Daily exposure to noise ranged from 88.4 to 89.4 dB. The noise levels of different frequencies ranged from 80.0 to 89.4 dB with a peak-value at 4 kHz. NAC significantly reduced TTS (p = 0.03). When the participants were grouped by GST M1/T1 genotypes, the NAC effect was only significant among workers with null genotypes in both GSTM1 and GSTT1 (p = 0.004). NAC may prevent noise-induced TTS among occupationally noise-exposed men. The protective effect of NAC was more prominent in subjects with both GSTM1-null and GSTT1-null genotypes. (clinicaltrials.gov Identifier: NCT00552786).

Original languageEnglish
Pages (from-to)42-47
Number of pages6
JournalHearing Research
Volume269
Issue number1-2
DOIs
Publication statusPublished - 2010 Oct 1

All Science Journal Classification (ASJC) codes

  • Sensory Systems

Fingerprint Dive into the research topics of 'N-Acetyl-cysteine against noise-induced temporary threshold shift in male workers'. Together they form a unique fingerprint.

  • Cite this