TY - JOUR
T1 - Nanofabricated SERS-active substrates for single-molecule to virus detection in vitro
T2 - A review
AU - Luo, Shyh Chyang
AU - Sivashanmugan, Kundan
AU - Liao, Jiunn Der
AU - Yao, Chih Kai
AU - Peng, Han Chi
N1 - Funding Information:
This work was financially supported by Ministry of Science and Technology of Taiwan (102-2113-M006-013-MY2 and 100-2221-E-006-025-MY3) and Medical Device Innovation Center of National Cheng Kung University (D102-21007).
PY - 2014/11/15
Y1 - 2014/11/15
N2 - The surface-enhanced Raman scattering (SERS) method has great potential for the detection of Raman-active species, ranging from single molecules to biomolecules. In the last five years, various approaches have been developed to fabricate SERS-active substrates with high sensitivity using noble metal nanostructures via top-down, bottom-up, combination, or template-assisted routes. Nanostructured substrates with high average SERS enhancement factors (EFs) can now be easily produced, with the EF depending strongly on the size and shape of the nanostructures that give rise to the effect. For SERS substrates to be used as a platform for applications such as trace detection and bio-sensing, several issues, including sensitivity, intensity-concentration dependency, and selectivity, need to be addressed. Although several challenges remain before SERS-active substrates become consistent analytical tools, many successful examples have been demonstrated with promising results.
AB - The surface-enhanced Raman scattering (SERS) method has great potential for the detection of Raman-active species, ranging from single molecules to biomolecules. In the last five years, various approaches have been developed to fabricate SERS-active substrates with high sensitivity using noble metal nanostructures via top-down, bottom-up, combination, or template-assisted routes. Nanostructured substrates with high average SERS enhancement factors (EFs) can now be easily produced, with the EF depending strongly on the size and shape of the nanostructures that give rise to the effect. For SERS substrates to be used as a platform for applications such as trace detection and bio-sensing, several issues, including sensitivity, intensity-concentration dependency, and selectivity, need to be addressed. Although several challenges remain before SERS-active substrates become consistent analytical tools, many successful examples have been demonstrated with promising results.
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U2 - 10.1016/j.bios.2014.05.013
DO - 10.1016/j.bios.2014.05.013
M3 - Article
C2 - 24892785
AN - SCOPUS:84901488813
SN - 0956-5663
VL - 61
SP - 232
EP - 240
JO - Biosensors and Bioelectronics
JF - Biosensors and Bioelectronics
ER -