Nanoshell magnetic resonance imaging contrast agents

Chia Hao Su, Hwo Shuenn Sheu, Chia Yun Lin, Chih Chia Huang, Yi Wei Lo, Ying Chih Pu, Jun Cheng Weng, Dar Bin Shieh, Jyh Horng Chen, Chen Sheng Yeh

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In our studies, Au3Cu1 hollow nanostructures are believed to be the first bimetallic MR contrast agents. AU3CU 1 nanocapsules enhanced signal contrast not only in Ti-weighted imaging, but also in T2-weighted imaging at lower doses. Herein, we believe that the cooperativity originating from the form of the nanoparticles and the large surface area of the water, because of porous hollow morphology of the nanoparticle, are primarily involved. Furthermore, the amine groups on the outermost PEI polymer shell of the nanocapsules, which further provide surface modification for the attachment of biological signals, suggest great potential for use in multifunctional composite capsules as functional carriers and imaging agents. Overall, these results might lead to the creation of other non-Gd- and non-iron oxide-based bimetallic contrast agents.

Original languageEnglish
Title of host publicationDigest of Papers - Microprocesses and Nanotechnology 2007; 20th International Microprocesses and Nanotechnology Conference, MNC
Pages272-273
Number of pages2
DOIs
Publication statusPublished - 2007 Dec 1
Events20th International Microprocesses and Nanotechnology Conference, MNC 2007 - Kyoto, Japan
Duration: 2007 Nov 52007 Nov 8

Publication series

NameDigest of Papers - Microprocesses and Nanotechnology 2007; 20th International Microprocesses and Nanotechnology Conference, MNC

Other

Others20th International Microprocesses and Nanotechnology Conference, MNC 2007
CountryJapan
CityKyoto
Period07-11-0507-11-08

All Science Journal Classification (ASJC) codes

  • Hardware and Architecture
  • Electrical and Electronic Engineering

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