Naphthoquinone esters from the root of Rhinacanthus nasutus

Tian Shung Wu, Hua Chun Hsu, Pei Lin Wu, Yann Lii Leu, Yu Yi Chan, Ching Yuh Chern, Mou Yung Yeh, Hsien Ju Tien

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50 Citations (Scopus)


Reinvestigation of the root of Rhinacanthus nasutus afforded, in addition to rhinacanthin-A to -D reported previously, two new dimethyldihydropyranonaphthoquinone esters (5, 6) and eight new 2-hydroxy- 1,4-naphthoquinone esters (7-14) were isolated. The stereochemistry of rhinacanthin-A was determined as the R configuration. Compounds rhinacanthin- G to -N, belong to a class of 2-hydroxy-3-(3-hydroxy-2,2-dimethylpropyl)- 1,4-naphthoquinone esters, and so far have been isolated only in this plant. Their biosynthesis is also discussed.

Original languageEnglish
Pages (from-to)413-418
Number of pages6
JournalChemical and Pharmaceutical Bulletin
Issue number3
Publication statusPublished - 1998 Jan 1

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

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