Near-infrared Au nanorods in photodynamic therapy, hyperthermia agents, and near-infrared optical imaging

Wen Shuo Kuo, Chich Neng Chang, Yi Ting Chang, Meng Heng Yang, Yi Hsin Chien, Shean Jen Chen, Chen-Sheng Yeh

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

The development of multifunctional nanomaterials is currently a topic of interest in the field of nanotechnology. Integrated systems that incorporate therapeutics, molecular targeting, and diagnostic imaging capabilities are considered to be the next generation of multifunctional nanomedicine. In this work, we present the first example of using Au nanorods simultaneously serving not only as photodynamic and photothermal agents to destroy A549 malignant cells but also as optical contrast agents simultaneously to monitor cellular image. Au nanorods were successfully conjugated with hydrophilic photosensitizer, indocyanine green (ICG), to achieve photodynamic therapy (PDT) and hyperthermia. With the combination of PDT and hyperthermia proved to be efficiently killing cancer cells as compared to PDT or hyperthermia treatment alone and enhanced the effectiveness of photodestruction. Moreover, Au nanorods conjugated with ICG displayed high chemical stability and simultaneously acted as a promising cellular image probe. As a result, the preparation of Au nanorods conjugated with photosensitizers as well as their use in biomedical applications is valuable developments in multifunctional nanomaterials.

Original languageEnglish
Title of host publicationReporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III
DOIs
Publication statusPublished - 2011 Apr 29
EventReporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III - San Francisco, CA, United States
Duration: 2011 Jan 242011 Jan 26

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7910
ISSN (Print)1605-7422

Other

OtherReporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III
CountryUnited States
CitySan Francisco, CA
Period11-01-2411-01-26

Fingerprint

Nanotubes
Photodynamic therapy
hyperthermia
Optical Imaging
Photochemotherapy
Nanorods
nanorods
therapy
Fever
Infrared radiation
Imaging techniques
Indocyanine Green
Photosensitizing Agents
Photosensitizers
Nanostructures
Nanostructured materials
Nanomedicine
Medical nanotechnology
Nanotechnology
Molecular Imaging

All Science Journal Classification (ASJC) codes

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Kuo, W. S., Chang, C. N., Chang, Y. T., Yang, M. H., Chien, Y. H., Chen, S. J., & Yeh, C-S. (2011). Near-infrared Au nanorods in photodynamic therapy, hyperthermia agents, and near-infrared optical imaging. In Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III [791009] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7910). https://doi.org/10.1117/12.876667
Kuo, Wen Shuo ; Chang, Chich Neng ; Chang, Yi Ting ; Yang, Meng Heng ; Chien, Yi Hsin ; Chen, Shean Jen ; Yeh, Chen-Sheng. / Near-infrared Au nanorods in photodynamic therapy, hyperthermia agents, and near-infrared optical imaging. Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III. 2011. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).
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Kuo, WS, Chang, CN, Chang, YT, Yang, MH, Chien, YH, Chen, SJ & Yeh, C-S 2011, Near-infrared Au nanorods in photodynamic therapy, hyperthermia agents, and near-infrared optical imaging. in Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III., 791009, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 7910, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III, San Francisco, CA, United States, 11-01-24. https://doi.org/10.1117/12.876667

Near-infrared Au nanorods in photodynamic therapy, hyperthermia agents, and near-infrared optical imaging. / Kuo, Wen Shuo; Chang, Chich Neng; Chang, Yi Ting; Yang, Meng Heng; Chien, Yi Hsin; Chen, Shean Jen; Yeh, Chen-Sheng.

Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III. 2011. 791009 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7910).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Kuo WS, Chang CN, Chang YT, Yang MH, Chien YH, Chen SJ et al. Near-infrared Au nanorods in photodynamic therapy, hyperthermia agents, and near-infrared optical imaging. In Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III. 2011. 791009. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). https://doi.org/10.1117/12.876667