Near-infrared Au nanorods in photodynamic therapy, hyperthermia agents, and near-infrared optical imaging

Wen Shuo Kuo; Chich Neng Chang; Yi Ting Chang; Meng Heng Yang; Yi Hsin Chien; Shean Jen Chen; Chen Sheng Yeh

doi:10.1117/12.876667

Near-infrared Au nanorods in photodynamic therapy, hyperthermia agents, and near-infrared optical imaging

Wen Shuo Kuo, Chich Neng Chang, Yi Ting Chang, Meng Heng Yang, Yi Hsin Chien, Shean Jen Chen, Chen Sheng Yeh

Department of Chemistry

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

3 Citations (Scopus)

Abstract

The development of multifunctional nanomaterials is currently a topic of interest in the field of nanotechnology. Integrated systems that incorporate therapeutics, molecular targeting, and diagnostic imaging capabilities are considered to be the next generation of multifunctional nanomedicine. In this work, we present the first example of using Au nanorods simultaneously serving not only as photodynamic and photothermal agents to destroy A549 malignant cells but also as optical contrast agents simultaneously to monitor cellular image. Au nanorods were successfully conjugated with hydrophilic photosensitizer, indocyanine green (ICG), to achieve photodynamic therapy (PDT) and hyperthermia. With the combination of PDT and hyperthermia proved to be efficiently killing cancer cells as compared to PDT or hyperthermia treatment alone and enhanced the effectiveness of photodestruction. Moreover, Au nanorods conjugated with ICG displayed high chemical stability and simultaneously acted as a promising cellular image probe. As a result, the preparation of Au nanorods conjugated with photosensitizers as well as their use in biomedical applications is valuable developments in multifunctional nanomaterials.

Original language	English
Title of host publication	Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III
DOIs	https://doi.org/10.1117/12.876667
Publication status	Published - 2011
Event	Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III - San Francisco, CA, United States Duration: 2011 Jan 24 → 2011 Jan 26

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	7910
ISSN (Print)	1605-7422

Other

Other	Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III
Country/Territory	United States
City	San Francisco, CA
Period	11-01-24 → 11-01-26

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
Biomaterials
Atomic and Molecular Physics, and Optics
Radiology Nuclear Medicine and imaging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1117/12.876667

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Kuo, W. S., Chang, C. N., Chang, Y. T., Yang, M. H., Chien, Y. H., Chen, S. J., & Yeh, C. S. (2011). Near-infrared Au nanorods in photodynamic therapy, hyperthermia agents, and near-infrared optical imaging. In Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III Article 791009 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7910). https://doi.org/10.1117/12.876667

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title = "Near-infrared Au nanorods in photodynamic therapy, hyperthermia agents, and near-infrared optical imaging",

abstract = "The development of multifunctional nanomaterials is currently a topic of interest in the field of nanotechnology. Integrated systems that incorporate therapeutics, molecular targeting, and diagnostic imaging capabilities are considered to be the next generation of multifunctional nanomedicine. In this work, we present the first example of using Au nanorods simultaneously serving not only as photodynamic and photothermal agents to destroy A549 malignant cells but also as optical contrast agents simultaneously to monitor cellular image. Au nanorods were successfully conjugated with hydrophilic photosensitizer, indocyanine green (ICG), to achieve photodynamic therapy (PDT) and hyperthermia. With the combination of PDT and hyperthermia proved to be efficiently killing cancer cells as compared to PDT or hyperthermia treatment alone and enhanced the effectiveness of photodestruction. Moreover, Au nanorods conjugated with ICG displayed high chemical stability and simultaneously acted as a promising cellular image probe. As a result, the preparation of Au nanorods conjugated with photosensitizers as well as their use in biomedical applications is valuable developments in multifunctional nanomaterials.",

author = "Kuo, {Wen Shuo} and Chang, {Chich Neng} and Chang, {Yi Ting} and Yang, {Meng Heng} and Chien, {Yi Hsin} and Chen, {Shean Jen} and Yeh, {Chen Sheng}",

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doi = "10.1117/12.876667",

language = "English",

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booktitle = "Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III",

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Kuo, WS, Chang, CN, Chang, YT, Yang, MH, Chien, YH, Chen, SJ & Yeh, CS 2011, Near-infrared Au nanorods in photodynamic therapy, hyperthermia agents, and near-infrared optical imaging. in Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III., 791009, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 7910, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III, San Francisco, CA, United States, 11-01-24. https://doi.org/10.1117/12.876667

Near-infrared Au nanorods in photodynamic therapy, hyperthermia agents, and near-infrared optical imaging. / Kuo, Wen Shuo; Chang, Chich Neng; Chang, Yi Ting et al.
Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III. 2011. 791009 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7910).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AU - Kuo, Wen Shuo

AU - Chang, Chich Neng

AU - Chang, Yi Ting

AU - Yang, Meng Heng

AU - Chien, Yi Hsin

AU - Chen, Shean Jen

AU - Yeh, Chen Sheng

PY - 2011

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N2 - The development of multifunctional nanomaterials is currently a topic of interest in the field of nanotechnology. Integrated systems that incorporate therapeutics, molecular targeting, and diagnostic imaging capabilities are considered to be the next generation of multifunctional nanomedicine. In this work, we present the first example of using Au nanorods simultaneously serving not only as photodynamic and photothermal agents to destroy A549 malignant cells but also as optical contrast agents simultaneously to monitor cellular image. Au nanorods were successfully conjugated with hydrophilic photosensitizer, indocyanine green (ICG), to achieve photodynamic therapy (PDT) and hyperthermia. With the combination of PDT and hyperthermia proved to be efficiently killing cancer cells as compared to PDT or hyperthermia treatment alone and enhanced the effectiveness of photodestruction. Moreover, Au nanorods conjugated with ICG displayed high chemical stability and simultaneously acted as a promising cellular image probe. As a result, the preparation of Au nanorods conjugated with photosensitizers as well as their use in biomedical applications is valuable developments in multifunctional nanomaterials.

AB - The development of multifunctional nanomaterials is currently a topic of interest in the field of nanotechnology. Integrated systems that incorporate therapeutics, molecular targeting, and diagnostic imaging capabilities are considered to be the next generation of multifunctional nanomedicine. In this work, we present the first example of using Au nanorods simultaneously serving not only as photodynamic and photothermal agents to destroy A549 malignant cells but also as optical contrast agents simultaneously to monitor cellular image. Au nanorods were successfully conjugated with hydrophilic photosensitizer, indocyanine green (ICG), to achieve photodynamic therapy (PDT) and hyperthermia. With the combination of PDT and hyperthermia proved to be efficiently killing cancer cells as compared to PDT or hyperthermia treatment alone and enhanced the effectiveness of photodestruction. Moreover, Au nanorods conjugated with ICG displayed high chemical stability and simultaneously acted as a promising cellular image probe. As a result, the preparation of Au nanorods conjugated with photosensitizers as well as their use in biomedical applications is valuable developments in multifunctional nanomaterials.

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T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III

T2 - Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III

Y2 - 24 January 2011 through 26 January 2011

ER -

Kuo WS, Chang CN, Chang YT, Yang MH, Chien YH, Chen SJ et al. Near-infrared Au nanorods in photodynamic therapy, hyperthermia agents, and near-infrared optical imaging. In Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III. 2011. 791009. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.876667

Near-infrared Au nanorods in photodynamic therapy, hyperthermia agents, and near-infrared optical imaging

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