TY - JOUR
T1 - Near-infrared light scattering and water diffusion in newborn brains
AU - Iwata, Sachiko
AU - Katayama, Reiji
AU - Tsuda, Kennosuke
AU - Lin, Yung Chieh
AU - Kurata, Tsuyoshi
AU - Kinoshita, Masahiro
AU - Kawase, Koya
AU - Kato, Takenori
AU - Kato, Shin
AU - Hisano, Tadashi
AU - Oda, Motoki
AU - Ohmae, Etsuko
AU - Takashima, Sachio
AU - Araki, Yuko
AU - Saitoh, Shinji
AU - Iwata, Osuke
N1 - Publisher Copyright:
© 2022 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.
PY - 2022/9
Y1 - 2022/9
N2 - Objective: MRI provides useful information regarding brain maturation and injury in newborn infants. However, MRI studies are generally restricted during acute phase, resulting in uncertainty around upstream clinical events responsible for subtle cerebral injuries. Time-resolved near-infrared spectroscopy non-invasively provides the reduced scattering coefficient ((Formula presented.)), which theoretically reflects tissue structural complexity. This study aimed to test whether (Formula presented.) values of the newborn head reflected MRI findings. Methods: Between June 2009 and January 2015, 77 hospitalised newborn infants (31.7 ± 3.8 weeks gestation) were assessed at 38.8 ± 1.3 weeks post-conceptional age. Associations of (Formula presented.) values with MRI scores, mean diffusivity and fractional anisotropy were assessed. Results: Univariable analysis showed that (Formula presented.) values were associated with gestational week (p = 0.035; regression coefficient [B], 0.065; 95% confidence interval [CI], 0.005–0.125), fractional anisotropy in the cortical grey matter (p = 0.020; B, −5.994; 95%CI, −11.032 to −0.957), average diffusivity in the cortical grey matter (p < 0.001; B, −4.728; 95%CI, −7.063 to −2.394) and subcortical white matter (p = 0.001; B, −2.071; 95%CI, −3.311 to −0.832), subarachnoid space (p < 0.001; B, −0.289; 95%CI, −0.376 to −0.201) and absence of brain abnormality (p = 0.042; B, −0.422; 95%CI, −0.829 to −0.015). The multivariable model to explain (Formula presented.) values comprised average diffusivity in the subcortical white matter (p < 0.001; B, −2.066; 95%CI, −3.200 to −0.932), subarachnoid space (p < 0.001; B, −0.314; 95%CI, −0.412 to −0.216) and absence of brain abnormality (p = 0.021; B, −0.400; 95%CI, −0.739 to −0.061). Interpretation: Light scattering was associated with brain structure indicated by MRI-assessed brain abnormality and diffusion-tensor-imaging-assessed water diffusivity. When serially assessed in a larger population, (Formula presented.) values might help identify covert clinical events responsible for subtle cerebral injury.
AB - Objective: MRI provides useful information regarding brain maturation and injury in newborn infants. However, MRI studies are generally restricted during acute phase, resulting in uncertainty around upstream clinical events responsible for subtle cerebral injuries. Time-resolved near-infrared spectroscopy non-invasively provides the reduced scattering coefficient ((Formula presented.)), which theoretically reflects tissue structural complexity. This study aimed to test whether (Formula presented.) values of the newborn head reflected MRI findings. Methods: Between June 2009 and January 2015, 77 hospitalised newborn infants (31.7 ± 3.8 weeks gestation) were assessed at 38.8 ± 1.3 weeks post-conceptional age. Associations of (Formula presented.) values with MRI scores, mean diffusivity and fractional anisotropy were assessed. Results: Univariable analysis showed that (Formula presented.) values were associated with gestational week (p = 0.035; regression coefficient [B], 0.065; 95% confidence interval [CI], 0.005–0.125), fractional anisotropy in the cortical grey matter (p = 0.020; B, −5.994; 95%CI, −11.032 to −0.957), average diffusivity in the cortical grey matter (p < 0.001; B, −4.728; 95%CI, −7.063 to −2.394) and subcortical white matter (p = 0.001; B, −2.071; 95%CI, −3.311 to −0.832), subarachnoid space (p < 0.001; B, −0.289; 95%CI, −0.376 to −0.201) and absence of brain abnormality (p = 0.042; B, −0.422; 95%CI, −0.829 to −0.015). The multivariable model to explain (Formula presented.) values comprised average diffusivity in the subcortical white matter (p < 0.001; B, −2.066; 95%CI, −3.200 to −0.932), subarachnoid space (p < 0.001; B, −0.314; 95%CI, −0.412 to −0.216) and absence of brain abnormality (p = 0.021; B, −0.400; 95%CI, −0.739 to −0.061). Interpretation: Light scattering was associated with brain structure indicated by MRI-assessed brain abnormality and diffusion-tensor-imaging-assessed water diffusivity. When serially assessed in a larger population, (Formula presented.) values might help identify covert clinical events responsible for subtle cerebral injury.
UR - https://www.scopus.com/pages/publications/85135565102
UR - https://www.scopus.com/pages/publications/85135565102#tab=citedBy
U2 - 10.1002/acn3.51641
DO - 10.1002/acn3.51641
M3 - Article
C2 - 35943446
AN - SCOPUS:85135565102
SN - 2328-9503
VL - 9
SP - 1417
EP - 1427
JO - Annals of Clinical and Translational Neurology
JF - Annals of Clinical and Translational Neurology
IS - 9
ER -