Neck xanthogranuloma mimicking malignancy in a patient with diabetes mellitus: A case report and literature review

Tzu Pai Chen, Wan Ling Yi, Chiang Shin Liu, Yu Hsuan Lin

Research output: Contribution to journalReview article

Abstract

Rationale: Xanthogranulomatous inflammation (XGI) is a rare inflammatory process, which mostly affects the kidney and gallbladder. It usually simulates an aggressive neoplastic process. Occurrences in the neck are extremely rare and would usually be associated with a preexisting cyst or glandular tissues. Patient concerns: A 49-year-old diabetic patient presented with a right painful neck mass for a week. The pretreatment computed tomography (CT) imaging with contrast demonstrated a huge ill-defined heterogeneous-enhanced lesion abutting surrounding musculatures and great vessels. Both fine needle aspiration (FNA) and ultrasound-guided core biopsy of the neck mass showed inflammatory cells only. Diagnoses: Histologic evaluation found granulation tissue with histiocytes and occasional Touton giant cells confirming the diagnosis of xanthogranuloma. Interventions: Open excisional biopsy demonstrated a yellowish mass-like lesion with abscess inside. Outcomes: The patient recovered from the disease without posttreatment comorbidities. Lessons: This case highlights the need for physicians to maintain awareness of this clinical entity and delayed- or overtreatment should be avoided in these patients due to preoperative ambiguous diagnosis.

Original languageEnglish
Article numbere12615
JournalMedicine (United States)
Volume97
Issue number40
DOIs
Publication statusPublished - 2018 Oct 1

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Diabetes Mellitus
Neck
Neoplasms
Neoplastic Processes
Biopsy
Histiocytes
Granulation Tissue
Giant Cells
Fine Needle Biopsy
Gallbladder
Abscess
Comorbidity
Cysts
Tomography
Inflammation
Physicians
Kidney

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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title = "Neck xanthogranuloma mimicking malignancy in a patient with diabetes mellitus: A case report and literature review",
abstract = "Rationale: Xanthogranulomatous inflammation (XGI) is a rare inflammatory process, which mostly affects the kidney and gallbladder. It usually simulates an aggressive neoplastic process. Occurrences in the neck are extremely rare and would usually be associated with a preexisting cyst or glandular tissues. Patient concerns: A 49-year-old diabetic patient presented with a right painful neck mass for a week. The pretreatment computed tomography (CT) imaging with contrast demonstrated a huge ill-defined heterogeneous-enhanced lesion abutting surrounding musculatures and great vessels. Both fine needle aspiration (FNA) and ultrasound-guided core biopsy of the neck mass showed inflammatory cells only. Diagnoses: Histologic evaluation found granulation tissue with histiocytes and occasional Touton giant cells confirming the diagnosis of xanthogranuloma. Interventions: Open excisional biopsy demonstrated a yellowish mass-like lesion with abscess inside. Outcomes: The patient recovered from the disease without posttreatment comorbidities. Lessons: This case highlights the need for physicians to maintain awareness of this clinical entity and delayed- or overtreatment should be avoided in these patients due to preoperative ambiguous diagnosis.",
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Neck xanthogranuloma mimicking malignancy in a patient with diabetes mellitus : A case report and literature review. / Chen, Tzu Pai; Yi, Wan Ling; Liu, Chiang Shin; Lin, Yu Hsuan.

In: Medicine (United States), Vol. 97, No. 40, e12615, 01.10.2018.

Research output: Contribution to journalReview article

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AU - Liu, Chiang Shin

AU - Lin, Yu Hsuan

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