Neonatal isolation delays the developmental decline of long-term depression in the CA1 region of rat hippocampus

Hsiao Yun Ku, Yu Fei Huang, Pei Hsuan Chao, Chiung Chun Huang, Kuei-Sen Hsu

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Activity-dependent alterations of synaptic efficacy or connectivity are essential for the development, signal processing, and learning and memory functions of the nervous system. It was observed that, in particular in the CA1 region of the hippocampus, low-frequency stimulation (LFS) became progressively less effective at inducing long-term depression (LTD) with advancing developmental age. The physiological factors regulating this developmental plasticity change, however, have not yet been elucidated. Here we examined the hypothesis that neonatal isolation (once per day for 1 h from postnatal days 1-7) is able to alter processes underlying the developmental decline of LTD. We confirm that the magnitude of LTD induced by LFS (900 stimuli at 1 Hz) protocol correlates negatively with developmental age and illustrates that neonatal isolation delays this developmental decline via the activation of corticotrophin-releasing factor (CRF) system. Furthermore, this modulation appears to be mediated by an increased transcription of N-methyl-D-aspartate receptor NR2B subunits. We also demonstrate that intracerebroventricular injection of CRF postnatally mimicked the effect of neonatal isolation to increase the expression of NR2B subunits and delayed the developmental decline of LTD, which was specifically blocked by CRF receptor 1 antagonist NBI27914 pretreatment. These results suggest a novel role for CRF in regulating developmental events in the hippocampus and indicate that although maternal deprivation is stressful for neonate, appropriate neonatal isolation can serve to promote an endocrine state that may regulate the gradual developmental change in the induction rules for synaptic plasticity in the hippocampal CA1 region.

Original languageEnglish
Pages (from-to)2847-2859
Number of pages13
JournalNeuropsychopharmacology
Volume33
Issue number12
DOIs
Publication statusPublished - 2008 Nov 1

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Corticotropin-Releasing Hormone
Hippocampus
Depression
Maternal Deprivation
Hippocampal CA1 Region
Neuronal Plasticity
Nervous System
Learning
Newborn Infant
Injections

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Psychiatry and Mental health

Cite this

Ku, Hsiao Yun ; Huang, Yu Fei ; Chao, Pei Hsuan ; Huang, Chiung Chun ; Hsu, Kuei-Sen. / Neonatal isolation delays the developmental decline of long-term depression in the CA1 region of rat hippocampus. In: Neuropsychopharmacology. 2008 ; Vol. 33, No. 12. pp. 2847-2859.
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Neonatal isolation delays the developmental decline of long-term depression in the CA1 region of rat hippocampus. / Ku, Hsiao Yun; Huang, Yu Fei; Chao, Pei Hsuan; Huang, Chiung Chun; Hsu, Kuei-Sen.

In: Neuropsychopharmacology, Vol. 33, No. 12, 01.11.2008, p. 2847-2859.

Research output: Contribution to journalArticle

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