Neonatal screening for alpha-thalassemia in southern Taiwan.

T. M. Lin, H. L. Eng, P. L. Kuo, H. L. Wu

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Screening peripheral or cord blood from newborn infants has been used for early detection of alpha-thalassemia conditions. The level of hemoglobin Bart's (Hb Bart's) in the blood correlates with the degree of alpha-gene deletion. Hence, the degree of gene deletion in an alpha-thalassemia carrier state can be estimated. Two thousand cord blood samples collected from the Tainan area were screened with cellulose acetate membrane electrophoresis for Hb Bart's. Ninety-nine of the 2,000 samples (4.95%) were positive for Hb Bart's. Concentrations of Hb Bart's varied from 3.2% to 30.7%. Of the 99 cases with Hb Bart's, 22 had Hb Bart's levels of 3.0% to 9.9%; 54 had Hb Bart's levels of 10.0% to 19.9%; and 23 had Hb Bart's levels of 20% to 40%. Routine cord blood screening by hemoglobin electrophoresis is recommended.

Original languageEnglish
Pages (from-to)1213-1215
Number of pages3
JournalJournal of the Formosan Medical Association = Taiwan yi zhi
Volume91
Issue number12
Publication statusPublished - 1992 Dec

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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