Neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced apoptosis in cultured cortical neurons

Yi Chien Lin; Li Chen Chou; Sheng Chih Chen; Sheng Chu Kuo; Li Jiau Huang; Po Wu Gean

doi:10.1016/j.bmcl.2009.04.101

Neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced apoptosis in cultured cortical neurons

Yi Chien Lin, Li Chen Chou, Sheng Chih Chen, Sheng Chu Kuo, Li Jiau Huang, Po Wu Gean

Department of Pharmacology

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Ceramide accumulation in neurons during various disorders is associated with acute and chronic neurodegeneration. Here we investigate the neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced cell death in primary cortical neurons. Among the 12 furopyrazole derivative of benzylindazole analogs tested, carbinol derivatives exhibited strongest neuroprotection against C2 ceramide-induced apoptosis. The results suggest that furopyrazole derivative of benzylindazole analogs can be developed as useful neuroprotectants against neurodegenerative diseases.

Original language	English
Pages (from-to)	3225-3228
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	12
DOIs	https://doi.org/10.1016/j.bmcl.2009.04.101
Publication status	Published - 2009 Jun 15

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2009.04.101

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title = "Neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced apoptosis in cultured cortical neurons",

abstract = "Ceramide accumulation in neurons during various disorders is associated with acute and chronic neurodegeneration. Here we investigate the neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced cell death in primary cortical neurons. Among the 12 furopyrazole derivative of benzylindazole analogs tested, carbinol derivatives exhibited strongest neuroprotection against C2 ceramide-induced apoptosis. The results suggest that furopyrazole derivative of benzylindazole analogs can be developed as useful neuroprotectants against neurodegenerative diseases.",

author = "Lin, {Yi Chien} and Chou, {Li Chen} and Chen, {Sheng Chih} and Kuo, {Sheng Chu} and Huang, {Li Jiau} and Gean, {Po Wu}",

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Neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced apoptosis in cultured cortical neurons. / Lin, Yi Chien; Chou, Li Chen; Chen, Sheng Chih; Kuo, Sheng Chu; Huang, Li Jiau; Gean, Po Wu.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 19, No. 12, 15.06.2009, p. 3225-3228.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced apoptosis in cultured cortical neurons

AU - Lin, Yi Chien

AU - Chou, Li Chen

AU - Chen, Sheng Chih

AU - Kuo, Sheng Chu

AU - Huang, Li Jiau

AU - Gean, Po Wu

PY - 2009/6/15

Y1 - 2009/6/15

N2 - Ceramide accumulation in neurons during various disorders is associated with acute and chronic neurodegeneration. Here we investigate the neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced cell death in primary cortical neurons. Among the 12 furopyrazole derivative of benzylindazole analogs tested, carbinol derivatives exhibited strongest neuroprotection against C2 ceramide-induced apoptosis. The results suggest that furopyrazole derivative of benzylindazole analogs can be developed as useful neuroprotectants against neurodegenerative diseases.

AB - Ceramide accumulation in neurons during various disorders is associated with acute and chronic neurodegeneration. Here we investigate the neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced cell death in primary cortical neurons. Among the 12 furopyrazole derivative of benzylindazole analogs tested, carbinol derivatives exhibited strongest neuroprotection against C2 ceramide-induced apoptosis. The results suggest that furopyrazole derivative of benzylindazole analogs can be developed as useful neuroprotectants against neurodegenerative diseases.

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Neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced apoptosis in cultured cortical neurons

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