Abstract
Ceramide accumulation in neurons during various disorders is associated with acute and chronic neurodegeneration. Here we investigate the neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced cell death in primary cortical neurons. Among the 12 furopyrazole derivative of benzylindazole analogs tested, carbinol derivatives exhibited strongest neuroprotection against C2 ceramide-induced apoptosis. The results suggest that furopyrazole derivative of benzylindazole analogs can be developed as useful neuroprotectants against neurodegenerative diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 3225-3228 |
| Number of pages | 4 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 19 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 2009 Jun 15 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry
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Neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced apoptosis in cultured cortical neurons. / Lin, Yi Chien; Chou, Li Chen; Chen, Sheng Chih; Kuo, Sheng Chu; Huang, Li Jiau; Gean, Po-Wu.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 19, No. 12, 15.06.2009, p. 3225-3228.Research output: Contribution to journal › Article
TY - JOUR
T1 - Neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced apoptosis in cultured cortical neurons
AU - Lin, Yi Chien
AU - Chou, Li Chen
AU - Chen, Sheng Chih
AU - Kuo, Sheng Chu
AU - Huang, Li Jiau
AU - Gean, Po-Wu
PY - 2009/6/15
Y1 - 2009/6/15
N2 - Ceramide accumulation in neurons during various disorders is associated with acute and chronic neurodegeneration. Here we investigate the neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced cell death in primary cortical neurons. Among the 12 furopyrazole derivative of benzylindazole analogs tested, carbinol derivatives exhibited strongest neuroprotection against C2 ceramide-induced apoptosis. The results suggest that furopyrazole derivative of benzylindazole analogs can be developed as useful neuroprotectants against neurodegenerative diseases.
AB - Ceramide accumulation in neurons during various disorders is associated with acute and chronic neurodegeneration. Here we investigate the neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced cell death in primary cortical neurons. Among the 12 furopyrazole derivative of benzylindazole analogs tested, carbinol derivatives exhibited strongest neuroprotection against C2 ceramide-induced apoptosis. The results suggest that furopyrazole derivative of benzylindazole analogs can be developed as useful neuroprotectants against neurodegenerative diseases.
UR - http://www.scopus.com/inward/record.url?scp=65749091452&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=65749091452&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2009.04.101
DO - 10.1016/j.bmcl.2009.04.101
M3 - Article
VL - 19
SP - 3225
EP - 3228
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 12
ER -