Neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced apoptosis in cultured cortical neurons

Yi Chien Lin, Li Chen Chou, Sheng Chih Chen, Sheng Chu Kuo, Li Jiau Huang, Po-Wu Gean

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Ceramide accumulation in neurons during various disorders is associated with acute and chronic neurodegeneration. Here we investigate the neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced cell death in primary cortical neurons. Among the 12 furopyrazole derivative of benzylindazole analogs tested, carbinol derivatives exhibited strongest neuroprotection against C2 ceramide-induced apoptosis. The results suggest that furopyrazole derivative of benzylindazole analogs can be developed as useful neuroprotectants against neurodegenerative diseases.

Original languageEnglish
Pages (from-to)3225-3228
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number12
DOIs
Publication statusPublished - 2009 Jun 15

Fingerprint

Neuroprotective Agents
Neurons
Apoptosis
Derivatives
Ceramides
Neurodegenerative Diseases
Methanol
Cell Death
Neurodegenerative diseases
Cell death
N-acetylsphingosine
Neuroprotection

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Lin, Yi Chien ; Chou, Li Chen ; Chen, Sheng Chih ; Kuo, Sheng Chu ; Huang, Li Jiau ; Gean, Po-Wu. / Neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced apoptosis in cultured cortical neurons. In: Bioorganic and Medicinal Chemistry Letters. 2009 ; Vol. 19, No. 12. pp. 3225-3228.
@article{0f33c93c161743dc85f79e005274b4d1,
title = "Neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced apoptosis in cultured cortical neurons",
abstract = "Ceramide accumulation in neurons during various disorders is associated with acute and chronic neurodegeneration. Here we investigate the neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced cell death in primary cortical neurons. Among the 12 furopyrazole derivative of benzylindazole analogs tested, carbinol derivatives exhibited strongest neuroprotection against C2 ceramide-induced apoptosis. The results suggest that furopyrazole derivative of benzylindazole analogs can be developed as useful neuroprotectants against neurodegenerative diseases.",
author = "Lin, {Yi Chien} and Chou, {Li Chen} and Chen, {Sheng Chih} and Kuo, {Sheng Chu} and Huang, {Li Jiau} and Po-Wu Gean",
year = "2009",
month = "6",
day = "15",
doi = "10.1016/j.bmcl.2009.04.101",
language = "English",
volume = "19",
pages = "3225--3228",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "12",

}

Neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced apoptosis in cultured cortical neurons. / Lin, Yi Chien; Chou, Li Chen; Chen, Sheng Chih; Kuo, Sheng Chu; Huang, Li Jiau; Gean, Po-Wu.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 19, No. 12, 15.06.2009, p. 3225-3228.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced apoptosis in cultured cortical neurons

AU - Lin, Yi Chien

AU - Chou, Li Chen

AU - Chen, Sheng Chih

AU - Kuo, Sheng Chu

AU - Huang, Li Jiau

AU - Gean, Po-Wu

PY - 2009/6/15

Y1 - 2009/6/15

N2 - Ceramide accumulation in neurons during various disorders is associated with acute and chronic neurodegeneration. Here we investigate the neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced cell death in primary cortical neurons. Among the 12 furopyrazole derivative of benzylindazole analogs tested, carbinol derivatives exhibited strongest neuroprotection against C2 ceramide-induced apoptosis. The results suggest that furopyrazole derivative of benzylindazole analogs can be developed as useful neuroprotectants against neurodegenerative diseases.

AB - Ceramide accumulation in neurons during various disorders is associated with acute and chronic neurodegeneration. Here we investigate the neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced cell death in primary cortical neurons. Among the 12 furopyrazole derivative of benzylindazole analogs tested, carbinol derivatives exhibited strongest neuroprotection against C2 ceramide-induced apoptosis. The results suggest that furopyrazole derivative of benzylindazole analogs can be developed as useful neuroprotectants against neurodegenerative diseases.

UR - http://www.scopus.com/inward/record.url?scp=65749091452&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65749091452&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2009.04.101

DO - 10.1016/j.bmcl.2009.04.101

M3 - Article

VL - 19

SP - 3225

EP - 3228

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 12

ER -