Neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced apoptosis in cultured cortical neurons

Yi Chien Lin, Li Chen Chou, Sheng Chih Chen, Sheng Chu Kuo, Li Jiau Huang, Po Wu Gean

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Ceramide accumulation in neurons during various disorders is associated with acute and chronic neurodegeneration. Here we investigate the neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced cell death in primary cortical neurons. Among the 12 furopyrazole derivative of benzylindazole analogs tested, carbinol derivatives exhibited strongest neuroprotection against C2 ceramide-induced apoptosis. The results suggest that furopyrazole derivative of benzylindazole analogs can be developed as useful neuroprotectants against neurodegenerative diseases.

Original languageEnglish
Pages (from-to)3225-3228
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number12
DOIs
Publication statusPublished - 2009 Jun 15

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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