Neuropsychological functions impairment in different subtypes of bipolar disorder with or without comorbid anxiety disorders

Chiao Ting Chang, Yun Hsuan Chang, Jo Yung-Wei Wu, Sheng Yu Lee, Shiou Lan Chen, Shih Heng Chen, Chun-Hsien Chu, Po-See Chen, I-Hui Lee, Tzung Lieh Yeh, Nian Sheng Tzeng, San Yuan Huang, Yen-Kuang Yang, Hsin Fen Yang, Ru-Band Lu

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9 Citations (Scopus)

Abstract

Bipolar disorder (BP) patients with comorbid anxiety disorders (ADs) showed more severe clinical characteristics and psychosocial function impairment, worse response to treatment, and more substance use than those without AD. However, few studies focus on differences in neuropsychological function between BP-I and BP-II and patients with and without AD. Seventy-nine BP patients in their interepisode state classified into four groups-BP-I without AD (BP-I-AD) (n=22), BP-I with AD (BP-I+AD) (n=20), BP-II without AD (BP-II-AD) (n=18), BP-II with AD (BP-II+AD) (n=19), and healthy controls (HC) (n=30)-were given neuropsychological tests. BP-I+AD patients did less well than BP-I-AD patients, but only in working memory. BP-II+AD patients did less well than the BP-II-AD patients in visual immediate memory, visual delayed memory, working memory, and psychomotor speed. BP-I+AD has limited effects on neuropsychological performance. However, significant effects were found only in BP-II+AD patients compared with BPII-AD patients. We hypothesized that comorbid AD worsens neuropsychological performance more in BP-II than in BP-I patients.

Original languageEnglish
Pages (from-to)246-251
Number of pages6
JournalPsychiatry Research
Volume200
Issue number2-3
DOIs
Publication statusPublished - 2012 Dec 30

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry

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  • Cite this

    Chang, C. T., Chang, Y. H., Yung-Wei Wu, J., Lee, S. Y., Chen, S. L., Chen, S. H., Chu, C-H., Chen, P-S., Lee, I-H., Lieh Yeh, T., Tzeng, N. S., Huang, S. Y., Yang, Y-K., Yang, H. F., & Lu, R-B. (2012). Neuropsychological functions impairment in different subtypes of bipolar disorder with or without comorbid anxiety disorders. Psychiatry Research, 200(2-3), 246-251. https://doi.org/10.1016/j.psychres.2012.06.012