Neuropsychological functions in Han Chinese patients in Taiwan with bipolar II disorder comorbid and not comorbid with alcohol abuse/alcohol dependence disorder

Cindy Shan, Sheng Yu Lee, Yun Hsuan Chang, Jo Yung Wei Wu, Shiou Lan Chen, Shih Heng Chen, Yih Lynn Hsiao, Hsin Fen Yang, I. Hui Lee, Po See Chen, Tzung Lieh Yeh, Yen Kuang Yang, Ru Band Lu

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Objective: Studies exploring neuropsychological functions of bipolar disorder (BP) specifically include patients comorbid with alcohol abuse (AB), alcohol dependence (AD), or both (AB/AD). Contradictory assessments of neuropsychological impairment may be caused by not excluding the confounding effects of comorbid AB/AD. Most of the literature discusses BP without subtyping, which overlooks that BP-II may be a valid diagnosis different from BP-I. Because neuropsychological functions are involved in overall BP-II outcomes, we hypothesized that the neuropsychological functions of patients with BP-II comorbid with AD (BP+AD) are significantly different from and more impaired than those of patients with BP-II not comorbid with AD (BP-AD). Methods: Using DSM-IV criteria, the study included 69 patients with BP-II (19 with BP+AD; 28 with BP-AD) and 22 healthy controls compared using a battery of neuropsychological tests that assessed memory, psychomotor speed, and certain aspects of frontal executive function. All BP-II patients were in an inter-episode period (a period of remission between states of mania, hypomania, and depression). Results: BP+AD patients had lower scores than did BP-AD patients and controls in verbal memory, visual memory, attention, psychomotor speed, and executive function. Working memory was poorer for BP+AD than BP-AD patients and for both BP groups than for controls. Conclusions: BP+AD patients manifested wide neuropsychological dysfunctions, and BP-AD patients showed a reduction in working memory, which suggested that working memory might be related to a history of BP-II. Neuropsychological dysfunctions seemed more strongly associated with AB/AD than with BP-II in inter-episode periods.

Original languageEnglish
Pages (from-to)131-136
Number of pages6
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume35
Issue number1
DOIs
Publication statusPublished - 2011 Jan 15

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Biological Psychiatry

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