New bioactive chromanes from litchi chinensis

Yu Chi Lin; Jia Chen Chang; Shi Yie Cheng; Chao Min Wang; Yun Lian Jhan; I. Wen Lo; Yuan Man Hsu; Chia Ching Liaw; Chi Chuan Hwang; Chang Hung Chou

doi:10.1021/jf5056387

New bioactive chromanes from litchi chinensis

Yu Chi Lin, Jia Chen Chang, Shi Yie Cheng, Chao Min Wang, Yun Lian Jhan, I. Wen Lo, Yuan Man Hsu, Chia Ching Liaw, Chi Chuan Hwang, Chang Hung Chou

Department of Engineering Science

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Seven new δ-tocotrienols, designated litchtocotrienols A-G (1-7), together with one glorious macrocyclic analogue, macrolitchtocotrienol A (8), and one new meroditerpene chromane, cyclolitchtocotrienol A (9), were isolated from the leaves of Litchi chinensis. Their structures were mainly determined by extensive spectroscopic analysis, and their biological activities were evaluated by cytotoxicity against human gastric adenocarcinoma cell lines (AGS, ATCC CRL-1739) and hepatoma carcinoma cell line (HepG2 2.2.1.5). The structure-activity relationship of the isolated compounds was also discussed.

Original language	English
Pages (from-to)	2472-2478
Number of pages	7
Journal	Journal of Agricultural and Food Chemistry
Volume	63
Issue number	9
DOIs	https://doi.org/10.1021/jf5056387
Publication status	Published - 2015 Feb

All Science Journal Classification (ASJC) codes

General Chemistry
General Agricultural and Biological Sciences

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10.1021/jf5056387

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title = "New bioactive chromanes from litchi chinensis",

abstract = "Seven new δ-tocotrienols, designated litchtocotrienols A-G (1-7), together with one glorious macrocyclic analogue, macrolitchtocotrienol A (8), and one new meroditerpene chromane, cyclolitchtocotrienol A (9), were isolated from the leaves of Litchi chinensis. Their structures were mainly determined by extensive spectroscopic analysis, and their biological activities were evaluated by cytotoxicity against human gastric adenocarcinoma cell lines (AGS, ATCC CRL-1739) and hepatoma carcinoma cell line (HepG2 2.2.1.5). The structure-activity relationship of the isolated compounds was also discussed.",

author = "Lin, {Yu Chi} and Chang, {Jia Chen} and Cheng, {Shi Yie} and Wang, {Chao Min} and Jhan, {Yun Lian} and Lo, {I. Wen} and Hsu, {Yuan Man} and Liaw, {Chia Ching} and Hwang, {Chi Chuan} and Chou, {Chang Hung}",

note = "Publisher Copyright: {\textcopyright} 2015 American Chemical Society.",

year = "2015",

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doi = "10.1021/jf5056387",

language = "English",

volume = "63",

pages = "2472--2478",

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TY - JOUR

T1 - New bioactive chromanes from litchi chinensis

AU - Lin, Yu Chi

AU - Chang, Jia Chen

AU - Cheng, Shi Yie

AU - Wang, Chao Min

AU - Jhan, Yun Lian

AU - Lo, I. Wen

AU - Hsu, Yuan Man

AU - Liaw, Chia Ching

AU - Hwang, Chi Chuan

AU - Chou, Chang Hung

PY - 2015/2

Y1 - 2015/2

N2 - Seven new δ-tocotrienols, designated litchtocotrienols A-G (1-7), together with one glorious macrocyclic analogue, macrolitchtocotrienol A (8), and one new meroditerpene chromane, cyclolitchtocotrienol A (9), were isolated from the leaves of Litchi chinensis. Their structures were mainly determined by extensive spectroscopic analysis, and their biological activities were evaluated by cytotoxicity against human gastric adenocarcinoma cell lines (AGS, ATCC CRL-1739) and hepatoma carcinoma cell line (HepG2 2.2.1.5). The structure-activity relationship of the isolated compounds was also discussed.

AB - Seven new δ-tocotrienols, designated litchtocotrienols A-G (1-7), together with one glorious macrocyclic analogue, macrolitchtocotrienol A (8), and one new meroditerpene chromane, cyclolitchtocotrienol A (9), were isolated from the leaves of Litchi chinensis. Their structures were mainly determined by extensive spectroscopic analysis, and their biological activities were evaluated by cytotoxicity against human gastric adenocarcinoma cell lines (AGS, ATCC CRL-1739) and hepatoma carcinoma cell line (HepG2 2.2.1.5). The structure-activity relationship of the isolated compounds was also discussed.

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JO - Journal of Agricultural and Food Chemistry

JF - Journal of Agricultural and Food Chemistry

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New bioactive chromanes from litchi chinensis

Abstract

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