New constituents and antiplatelet aggregation and anti-HIV principles of Artemisia capillaris

Tian Shung Wu, Zhih Jing Tsang, Pei Lin Wu, Fu Wen Lin, Chia Yin Li, Che Ming Teng, Kuo Hsiung Lee

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Five new constituents including a flavonoid, artemisidin A (1), and four coumarins, artemicapins A (2), B (3), C (4) and D (5), together with 70 known compounds (6-75), have been isolated and characterized from the aerial part of Artemisia capillaris. The structures of these compounds were determined from spectral analyses and/or chemical evidence. Among them, 15 compounds (3, 6, 10, 18, 30-32, 38-41, 44, 45, 51, and 55) showed antiplatelet aggregation activity and three compounds (10, 17, and 51) demonstrated significant activity against HIV replication in H9 lymphocytic cells.

Original languageEnglish
Pages (from-to)77-83
Number of pages7
JournalBioorganic and Medicinal Chemistry
Volume9
Issue number1
DOIs
Publication statusPublished - 2001 Jan 8

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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