New diterpenoids and the bioactivity of Erythrophleum fordii

Chuan Chung Tsao, Yuh Chiang Shen, Chung Ren Su, Chia Ying Li, Meei Jen Liou, Nguyen Xuan Dung, Tian Shung Wu

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

A phytochemical investigation of the leaves of Erythrophleum fordii Oliv. has led to the isolation of three new cassaine-type diterpenoids, erythrofordin A (1), erythrofordin B (2) and erythrofordin C (3), as well as a norcassaine diterpenoid with a novel skeleton, norerythrofordin A (4), and 27 known compounds (5-31). The structures of 1-4 were elucidated on the basis of spectroscopic analysis. Selected compounds from this plant were examined for anti-inflammatory activity. Taraxerol (16) displayed potent NO-reducing activity in microglial cells, and gallic acid (27) exhibited excellent DPPH radical-scavenging effects. Crown

Original languageEnglish
Pages (from-to)9867-9870
Number of pages4
JournalBioorganic and Medicinal Chemistry
Volume16
Issue number22
DOIs
Publication statusPublished - 2008 Nov 15

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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