New insights into the functions and regulation of the transcriptional corepressors SMRT and N-CoR

Kristopher J. Stanya, Hung Ying Kao

Research output: Contribution to journalReview article

26 Citations (Scopus)

Abstract

Corepressors are large proteins that facilitate transcriptional repression through recruitment of histone-modifying enzymes. Two major corepressors, SMRT (silencing mediator for retinoid and thyroid hormone receptors) and N-CoR (nuclear receptor corepressor), have been shown to mediate repression associated with nuclear receptors and a myriad of other transcription factors. This review will focus on recent studies on these proteins, including newly discovered physiological roles of the corepressors, their modes of regulation, their roles in antiestrogen-resistant breast cancer and their functions during the cell cycle.

Original languageEnglish
Article number7
JournalCell Division
Volume4
DOIs
Publication statusPublished - 2009 Apr 21

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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