New N-substituted (±)-dehydronorglaucine analogs

Violeta Benedetti-Doctorovich; Fu Yung Huang; John Lambropoulos; Edward M. Burgess; Leon H. Zalkow

doi:10.1080/00397919508015508

New N-substituted (±)-dehydronorglaucine analogs

Violeta Benedetti-Doctorovich, Fu Yung Huang, John Lambropoulos, Edward M. Burgess, Leon H. Zalkow

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The aporphine alkaloid N-carbethoxydehydronorglaucine (1) was found to have promising in vitro antitumor activity, but poor water solubility. We report the synthesis of 1, the efficient hydrolysis of its urethane group and the further transformation into several new dehydronorglaucine analogs.

Original language	English
Pages (from-to)	3701-3709
Number of pages	9
Journal	Synthetic Communications
Volume	25
Issue number	22
DOIs	https://doi.org/10.1080/00397919508015508
Publication status	Published - 1995 Nov 1

All Science Journal Classification (ASJC) codes

Organic Chemistry

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title = "New N-substituted (±)-dehydronorglaucine analogs",

abstract = "The aporphine alkaloid N-carbethoxydehydronorglaucine (1) was found to have promising in vitro antitumor activity, but poor water solubility. We report the synthesis of 1, the efficient hydrolysis of its urethane group and the further transformation into several new dehydronorglaucine analogs.",

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AU - Huang, Fu Yung

AU - Lambropoulos, John

AU - Burgess, Edward M.

AU - Zalkow, Leon H.

PY - 1995/11/1

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