New N-substituted (±)-dehydronorglaucine analogs

Violeta Benedetti-Doctorovich, Fu Yung Huang, John Lambropoulos, Edward M. Burgess, Leon H. Zalkow

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

The aporphine alkaloid N-carbethoxydehydronorglaucine (1) was found to have promising in vitro antitumor activity, but poor water solubility. We report the synthesis of 1, the efficient hydrolysis of its urethane group and the further transformation into several new dehydronorglaucine analogs.

Original languageEnglish
Pages (from-to)3701-3709
Number of pages9
JournalSynthetic Communications
Volume25
Issue number22
DOIs
Publication statusPublished - 1995 Nov 1

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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