TY - JOUR
T1 - New N-substituted (±)-dehydronorglaucine analogs
AU - Benedetti-Doctorovich, Violeta
AU - Huang, Fu Yung
AU - Lambropoulos, John
AU - Burgess, Edward M.
AU - Zalkow, Leon H.
N1 - Funding Information:
Ackn0wledgement:We gratefully acknowledge support of this work by NCI
PY - 1995/11/1
Y1 - 1995/11/1
N2 - The aporphine alkaloid N-carbethoxydehydronorglaucine (1) was found to have promising in vitro antitumor activity, but poor water solubility. We report the synthesis of 1, the efficient hydrolysis of its urethane group and the further transformation into several new dehydronorglaucine analogs.
AB - The aporphine alkaloid N-carbethoxydehydronorglaucine (1) was found to have promising in vitro antitumor activity, but poor water solubility. We report the synthesis of 1, the efficient hydrolysis of its urethane group and the further transformation into several new dehydronorglaucine analogs.
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U2 - 10.1080/00397919508015508
DO - 10.1080/00397919508015508
M3 - Article
AN - SCOPUS:0029091074
VL - 25
SP - 3701
EP - 3709
JO - Synthetic Communications
JF - Synthetic Communications
SN - 0039-7911
IS - 22
ER -