TY - JOUR
T1 - Nisoxetine produces local but not systemic analgesia against cutaneous nociceptive stimuli in the rat
AU - Chen, Yu Wen
AU - Chu, Chin Chen
AU - Chen, Yu Chung
AU - Wang, Jhi Joung
AU - Hung, Ching Hsia
AU - Shao, Dong Zi
N1 - Funding Information:
The financial support provided for this study by the National Science Council of Taiwan ( NSC 99-2314-B-039-013-MY3 ; NSC 100-2314-B-039 -017-MY3 ).
PY - 2012/1/30
Y1 - 2012/1/30
N2 - The aim of this study was to evaluate the local anesthetic effect of nisoxetine as infiltrative cutaneous analgesic. After rats were injected subcutaneously with nisoxetine, dose-response curves were constructed. The cutaneous anesthetic effect of nisoxetine or MK-801 (dizocilpine) was compared with lidocaine, a traditional local anesthetic. We found that nisoxetine and MK-801 acted like lidocaine and elicited dose-related cutaneous (local) anesthesia. The relative potency was nisoxetine > MK-801 > lidocaine (P<0.01) as infiltrative anesthesia of skin. On an equianesthetic doses (20% effective dose [ED 20], ED 50, and ED 80), nisoxetine produced longer action of cutaneous anesthesia than that of lidocaine or MK-801 (P < 0.01). Coadministration of nisoxetine or lidocaine with MK-801 showed an additive cutaneous anesthesia. Neither local injection of a large dose of nisoxetine, MK-801 nor lidocaine in the thigh area produced cutaneous anesthesia (data not shown). In conclusion, nisoxetine had a local anesthetic effect as infiltrative cutaneous analgesia with durations of actions longer than that of lidocaine or MK-801. That N-methyl-d-aspartate receptors may not contribute to the cutaneous (local) anesthetic effect of nisoxetine or lidocaine.
AB - The aim of this study was to evaluate the local anesthetic effect of nisoxetine as infiltrative cutaneous analgesic. After rats were injected subcutaneously with nisoxetine, dose-response curves were constructed. The cutaneous anesthetic effect of nisoxetine or MK-801 (dizocilpine) was compared with lidocaine, a traditional local anesthetic. We found that nisoxetine and MK-801 acted like lidocaine and elicited dose-related cutaneous (local) anesthesia. The relative potency was nisoxetine > MK-801 > lidocaine (P<0.01) as infiltrative anesthesia of skin. On an equianesthetic doses (20% effective dose [ED 20], ED 50, and ED 80), nisoxetine produced longer action of cutaneous anesthesia than that of lidocaine or MK-801 (P < 0.01). Coadministration of nisoxetine or lidocaine with MK-801 showed an additive cutaneous anesthesia. Neither local injection of a large dose of nisoxetine, MK-801 nor lidocaine in the thigh area produced cutaneous anesthesia (data not shown). In conclusion, nisoxetine had a local anesthetic effect as infiltrative cutaneous analgesia with durations of actions longer than that of lidocaine or MK-801. That N-methyl-d-aspartate receptors may not contribute to the cutaneous (local) anesthetic effect of nisoxetine or lidocaine.
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U2 - 10.1016/j.ejphar.2011.11.042
DO - 10.1016/j.ejphar.2011.11.042
M3 - Article
C2 - 22166377
AN - SCOPUS:84855450506
SN - 0014-2999
VL - 675
SP - 22
EP - 25
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 1-3
ER -