NMDA receptor-independent epileptiform activity induced by magnesium-free solution in rat amygdala neurons is blocked by CNQX

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The effect of 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), a specific non-N-methyl-d-aspartate (non-NMDA) receptor antagonist, on NMDA-independent epileptiform activity induced by Mg2+-free medium was studied in rat basolateral amygdala (BLA) neurons using intracellular recording techniques. Twenty to 30 min after switching to Mg2+-free medium, spontaneous and evoked epileptiform activity were observed in 16 out of 18 amygdala slices. Superfusion of d-2-amino-5-phosphonovalerate (d-APV), a selective NMDA receptor antagonist, reduced the duration of epileptiform activity by an average of 83%. However, there was a residual depolarizing component which remained in the presence of d-APV. This d-APV-resistant component could be completely blocked by CNQX suggesting that it is mediated by non-NMDA receptors.

Original languageEnglish
Pages (from-to)53-55
Number of pages3
JournalNeuroscience Letters
Volume119
Issue number1
DOIs
Publication statusPublished - 1990 Oct 30

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'NMDA receptor-independent epileptiform activity induced by magnesium-free solution in rat amygdala neurons is blocked by CNQX'. Together they form a unique fingerprint.

  • Cite this