No association between alcoholism and multiple polymorphisms at the dopamine D2 receptor gene (DRD2) in three distinct taiwanese populations

Ru Band Lu, Huei Chen Ko, Fong Ming Chang, Carmela M. Castiglione, Gloria Schoolfield, Andrew J. Pakstis, Judith R. Kidd, Kenneth K. Kidd

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Abstract

This study examined whether there is evidence for an association between alcoholism and the alleles of the TaqI A, TaqI B, and short tandem repeat polymorphisms (STRP), both individually and as haplotypes, at the dopamine D2 receptor gene (DRD2) in males of three populations from Taiwan. We studied 46 Chinese Han (21 alcoholics and 25 nonalcoholics), 42 Atayal (21 alcoholics and 21 nonalcoholics), and 40 Ami (20 alcoholics and 20 nonalcoholics). Alcoholism was diagnosed according to DSM-III-R criteria and all individuals in the alcoholic groups were severely affected. Significant linkage disequilibrium occurs for the three polymorphic sites in all three populations. No significant association was observed between any of the three polymorphisms at the DRD2 locus, tested individually and as haplotypes, and alcoholism in the three subject groups. We conclude that no association exists between genetic variation at the DRD2 locus and alcoholism in Chinese Han, Atayal, and Ami males.

Original languageEnglish
Pages (from-to)419-429
Number of pages11
JournalBiological Psychiatry
Volume39
Issue number6
DOIs
Publication statusPublished - 1996 Mar 15

All Science Journal Classification (ASJC) codes

  • Biological Psychiatry

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    Lu, R. B., Ko, H. C., Chang, F. M., Castiglione, C. M., Schoolfield, G., Pakstis, A. J., Kidd, J. R., & Kidd, K. K. (1996). No association between alcoholism and multiple polymorphisms at the dopamine D2 receptor gene (DRD2) in three distinct taiwanese populations. Biological Psychiatry, 39(6), 419-429. https://doi.org/10.1016/0006-3223(95)00182-4