TY - JOUR
T1 - No association between alcoholism and multiple polymorphisms at the dopamine D2 receptor gene (DRD2) in three distinct taiwanese populations
AU - Lu, Ru Band
AU - Ko, Huei Chen
AU - Chang, Fong Ming
AU - Castiglione, Carmela M.
AU - Schoolfield, Gloria
AU - Pakstis, Andrew J.
AU - Kidd, Judith R.
AU - Kidd, Kenneth K.
N1 - Funding Information:
This work was supported in part by a grant to RBL and FMC from the
PY - 1996/3/15
Y1 - 1996/3/15
N2 - This study examined whether there is evidence for an association between alcoholism and the alleles of the TaqI A, TaqI B, and short tandem repeat polymorphisms (STRP), both individually and as haplotypes, at the dopamine D2 receptor gene (DRD2) in males of three populations from Taiwan. We studied 46 Chinese Han (21 alcoholics and 25 nonalcoholics), 42 Atayal (21 alcoholics and 21 nonalcoholics), and 40 Ami (20 alcoholics and 20 nonalcoholics). Alcoholism was diagnosed according to DSM-III-R criteria and all individuals in the alcoholic groups were severely affected. Significant linkage disequilibrium occurs for the three polymorphic sites in all three populations. No significant association was observed between any of the three polymorphisms at the DRD2 locus, tested individually and as haplotypes, and alcoholism in the three subject groups. We conclude that no association exists between genetic variation at the DRD2 locus and alcoholism in Chinese Han, Atayal, and Ami males.
AB - This study examined whether there is evidence for an association between alcoholism and the alleles of the TaqI A, TaqI B, and short tandem repeat polymorphisms (STRP), both individually and as haplotypes, at the dopamine D2 receptor gene (DRD2) in males of three populations from Taiwan. We studied 46 Chinese Han (21 alcoholics and 25 nonalcoholics), 42 Atayal (21 alcoholics and 21 nonalcoholics), and 40 Ami (20 alcoholics and 20 nonalcoholics). Alcoholism was diagnosed according to DSM-III-R criteria and all individuals in the alcoholic groups were severely affected. Significant linkage disequilibrium occurs for the three polymorphic sites in all three populations. No significant association was observed between any of the three polymorphisms at the DRD2 locus, tested individually and as haplotypes, and alcoholism in the three subject groups. We conclude that no association exists between genetic variation at the DRD2 locus and alcoholism in Chinese Han, Atayal, and Ami males.
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U2 - 10.1016/0006-3223(95)00182-4
DO - 10.1016/0006-3223(95)00182-4
M3 - Article
C2 - 8679787
AN - SCOPUS:0030002965
SN - 0006-3223
VL - 39
SP - 419
EP - 429
JO - Biological Psychiatry
JF - Biological Psychiatry
IS - 6
ER -