Non-invasive synergistic treatment of brain tumors by targeted chemotherapeutic delivery and amplified focused ultrasound-hyperthermia using magnetic nanographene oxide

Hung Wei Yang; Mu Yi Hua; Tsong Long Hwang; Kun Ju Lin; Chiung Yin Huang; Rung Ywan Tsai; Chen Chi M. Ma; Po Hung Hsu; Shiaw Pyng Wey; Peng Wei Hsu; Pin Yuan Chen; Yin Cheng Huang; Yu Jen Lu; Tzu Chen Yen; Li Ying Feng; Chih Wen Lin; Hao Li Liu; Kuo Chen Wei

doi:10.1002/adma.201301046

Non-invasive synergistic treatment of brain tumors by targeted chemotherapeutic delivery and amplified focused ultrasound-hyperthermia using magnetic nanographene oxide

Hung Wei Yang, Mu Yi Hua, Tsong Long Hwang, Kun Ju Lin, Chiung Yin Huang, Rung Ywan Tsai, Chen Chi M. Ma, Po Hung Hsu, Shiaw Pyng Wey, Peng Wei Hsu, Pin Yuan Chen, Yin Cheng Huang, Yu Jen Lu, Tzu Chen Yen, Li Ying Feng, Chih Wen Lin, Hao Li Liu, Kuo Chen Wei

Department of Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

74 Citations (Scopus)

Abstract

The combination of chemo-thermal therapy is the best strategy to ablate tumors, but how to heat deep tumor tissues effectively without side-damage is a challenge. Here, a systemically delivered nanocarrier is designed with multiple advantages, including superior heat absorption, highly efficient hyperthermia, high drug capacity, specific targeting ability, and molecular imaging, to achieve both high antitumor efficacy and effective amplification of hyperthermia with minimal side effects.

Original language	English
Pages (from-to)	3605-3611
Number of pages	7
Journal	Advanced Materials
Volume	25
Issue number	26
DOIs	https://doi.org/10.1002/adma.201301046
Publication status	Published - 2013 Jul 12

All Science Journal Classification (ASJC) codes

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

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Yang, H. W., Hua, M. Y., Hwang, T. L., Lin, K. J., Huang, C. Y., Tsai, R. Y., Ma, C. C. M., Hsu, P. H., Wey, S. P., Hsu, P. W., Chen, P. Y., Huang, Y. C., Lu, Y. J., Yen, T. C., Feng, L. Y., Lin, C. W., Liu, H. L., & Wei, K. C. (2013). Non-invasive synergistic treatment of brain tumors by targeted chemotherapeutic delivery and amplified focused ultrasound-hyperthermia using magnetic nanographene oxide. Advanced Materials, 25(26), 3605-3611. https://doi.org/10.1002/adma.201301046

@article{c73332faecc940fcb248b866399572fa,

title = "Non-invasive synergistic treatment of brain tumors by targeted chemotherapeutic delivery and amplified focused ultrasound-hyperthermia using magnetic nanographene oxide",

abstract = "The combination of chemo-thermal therapy is the best strategy to ablate tumors, but how to heat deep tumor tissues effectively without side-damage is a challenge. Here, a systemically delivered nanocarrier is designed with multiple advantages, including superior heat absorption, highly efficient hyperthermia, high drug capacity, specific targeting ability, and molecular imaging, to achieve both high antitumor efficacy and effective amplification of hyperthermia with minimal side effects.",

author = "Yang, {Hung Wei} and Hua, {Mu Yi} and Hwang, {Tsong Long} and Lin, {Kun Ju} and Huang, {Chiung Yin} and Tsai, {Rung Ywan} and Ma, {Chen Chi M.} and Hsu, {Po Hung} and Wey, {Shiaw Pyng} and Hsu, {Peng Wei} and Chen, {Pin Yuan} and Huang, {Yin Cheng} and Lu, {Yu Jen} and Yen, {Tzu Chen} and Feng, {Li Ying} and Lin, {Chih Wen} and Liu, {Hao Li} and Wei, {Kuo Chen}",

year = "2013",

month = jul,

day = "12",

doi = "10.1002/adma.201301046",

language = "English",

volume = "25",

pages = "3605--3611",

journal = "Advanced Materials",

issn = "0935-9648",

publisher = "Wiley-VCH Verlag",

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}

Yang, HW, Hua, MY, Hwang, TL, Lin, KJ, Huang, CY, Tsai, RY, Ma, CCM, Hsu, PH, Wey, SP, Hsu, PW, Chen, PY, Huang, YC, Lu, YJ, Yen, TC, Feng, LY, Lin, CW, Liu, HL & Wei, KC 2013, 'Non-invasive synergistic treatment of brain tumors by targeted chemotherapeutic delivery and amplified focused ultrasound-hyperthermia using magnetic nanographene oxide', Advanced Materials, vol. 25, no. 26, pp. 3605-3611. https://doi.org/10.1002/adma.201301046

TY - JOUR

T1 - Non-invasive synergistic treatment of brain tumors by targeted chemotherapeutic delivery and amplified focused ultrasound-hyperthermia using magnetic nanographene oxide

AU - Yang, Hung Wei

AU - Hua, Mu Yi

AU - Hwang, Tsong Long

AU - Lin, Kun Ju

AU - Huang, Chiung Yin

AU - Tsai, Rung Ywan

AU - Ma, Chen Chi M.

AU - Hsu, Po Hung

AU - Wey, Shiaw Pyng

AU - Hsu, Peng Wei

AU - Chen, Pin Yuan

AU - Huang, Yin Cheng

AU - Lu, Yu Jen

AU - Yen, Tzu Chen

AU - Feng, Li Ying

AU - Lin, Chih Wen

AU - Liu, Hao Li

AU - Wei, Kuo Chen

PY - 2013/7/12

Y1 - 2013/7/12

N2 - The combination of chemo-thermal therapy is the best strategy to ablate tumors, but how to heat deep tumor tissues effectively without side-damage is a challenge. Here, a systemically delivered nanocarrier is designed with multiple advantages, including superior heat absorption, highly efficient hyperthermia, high drug capacity, specific targeting ability, and molecular imaging, to achieve both high antitumor efficacy and effective amplification of hyperthermia with minimal side effects.

AB - The combination of chemo-thermal therapy is the best strategy to ablate tumors, but how to heat deep tumor tissues effectively without side-damage is a challenge. Here, a systemically delivered nanocarrier is designed with multiple advantages, including superior heat absorption, highly efficient hyperthermia, high drug capacity, specific targeting ability, and molecular imaging, to achieve both high antitumor efficacy and effective amplification of hyperthermia with minimal side effects.

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DO - 10.1002/adma.201301046

M3 - Article

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AN - SCOPUS:84879945151

SN - 0935-9648

VL - 25

SP - 3605

EP - 3611

JO - Advanced Materials

JF - Advanced Materials

IS - 26

ER -

Non-invasive synergistic treatment of brain tumors by targeted chemotherapeutic delivery and amplified focused ultrasound-hyperthermia using magnetic nanographene oxide

Abstract

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