Non-invasive tumor detection using NIR light

Yung Chi Lin, Sheng Hao Tseng, Pau Choo Chung, Ching Fang Yang, Ming Han Wu, Shoko Nioka, Yong Kie Wong

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper presents a non-invasive device with near-infrared (NIR) light for the analysis of tissue components, particularly the blood oxygen saturation and hemoglobin concentration, by using photon diffusion equation. The device equips with a multispectral (7 wavelengths) LED and multiple sensors of different spatial distances to the LED source. An optimal fitting of the measurement data obtained from these sensors is employed to achieve a more accurate estimation of the concentrations of tissue components, such as hemoglobin, water, and lipid of tissue samples, which are often referred in clinic diagnosis. Besides, Monte Carlo simulation is applied to analyze how photons transmit in tissue under different depth levels. According to the simulation results, the proposal introduces a method for tumor detection to reduce the effect of shallow layer and to increase detection accuracy for deep layer tumors. The device was also evaluated by phantoms and clinical data acquired from the patients with neck tumors. Results indicate that our device is not only sensitive to the presence of neck tumors but also can be applied to study other clinical diseases.

Original languageEnglish
Title of host publication2013 IEEE Biomedical Circuits and Systems Conference, BioCAS 2013
Pages122-125
Number of pages4
DOIs
Publication statusPublished - 2013 Dec 1
Event2013 IEEE Biomedical Circuits and Systems Conference, BioCAS 2013 - Rotterdam, Netherlands
Duration: 2013 Oct 312013 Nov 2

Publication series

Name2013 IEEE Biomedical Circuits and Systems Conference, BioCAS 2013

Other

Other2013 IEEE Biomedical Circuits and Systems Conference, BioCAS 2013
CountryNetherlands
CityRotterdam
Period13-10-3113-11-02

Fingerprint

Tumors
Tissue
Infrared radiation
Hemoglobin
Light emitting diodes
Photons
Sensors
Lipids
Blood
Wavelength
Oxygen
Water

All Science Journal Classification (ASJC) codes

  • Hardware and Architecture
  • Biomedical Engineering
  • Electrical and Electronic Engineering

Cite this

Lin, Y. C., Tseng, S. H., Chung, P. C., Yang, C. F., Wu, M. H., Nioka, S., & Wong, Y. K. (2013). Non-invasive tumor detection using NIR light. In 2013 IEEE Biomedical Circuits and Systems Conference, BioCAS 2013 (pp. 122-125). [6679654] (2013 IEEE Biomedical Circuits and Systems Conference, BioCAS 2013). https://doi.org/10.1109/BioCAS.2013.6679654
Lin, Yung Chi ; Tseng, Sheng Hao ; Chung, Pau Choo ; Yang, Ching Fang ; Wu, Ming Han ; Nioka, Shoko ; Wong, Yong Kie. / Non-invasive tumor detection using NIR light. 2013 IEEE Biomedical Circuits and Systems Conference, BioCAS 2013. 2013. pp. 122-125 (2013 IEEE Biomedical Circuits and Systems Conference, BioCAS 2013).
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abstract = "This paper presents a non-invasive device with near-infrared (NIR) light for the analysis of tissue components, particularly the blood oxygen saturation and hemoglobin concentration, by using photon diffusion equation. The device equips with a multispectral (7 wavelengths) LED and multiple sensors of different spatial distances to the LED source. An optimal fitting of the measurement data obtained from these sensors is employed to achieve a more accurate estimation of the concentrations of tissue components, such as hemoglobin, water, and lipid of tissue samples, which are often referred in clinic diagnosis. Besides, Monte Carlo simulation is applied to analyze how photons transmit in tissue under different depth levels. According to the simulation results, the proposal introduces a method for tumor detection to reduce the effect of shallow layer and to increase detection accuracy for deep layer tumors. The device was also evaluated by phantoms and clinical data acquired from the patients with neck tumors. Results indicate that our device is not only sensitive to the presence of neck tumors but also can be applied to study other clinical diseases.",
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Lin, YC, Tseng, SH, Chung, PC, Yang, CF, Wu, MH, Nioka, S & Wong, YK 2013, Non-invasive tumor detection using NIR light. in 2013 IEEE Biomedical Circuits and Systems Conference, BioCAS 2013., 6679654, 2013 IEEE Biomedical Circuits and Systems Conference, BioCAS 2013, pp. 122-125, 2013 IEEE Biomedical Circuits and Systems Conference, BioCAS 2013, Rotterdam, Netherlands, 13-10-31. https://doi.org/10.1109/BioCAS.2013.6679654

Non-invasive tumor detection using NIR light. / Lin, Yung Chi; Tseng, Sheng Hao; Chung, Pau Choo; Yang, Ching Fang; Wu, Ming Han; Nioka, Shoko; Wong, Yong Kie.

2013 IEEE Biomedical Circuits and Systems Conference, BioCAS 2013. 2013. p. 122-125 6679654 (2013 IEEE Biomedical Circuits and Systems Conference, BioCAS 2013).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Lin YC, Tseng SH, Chung PC, Yang CF, Wu MH, Nioka S et al. Non-invasive tumor detection using NIR light. In 2013 IEEE Biomedical Circuits and Systems Conference, BioCAS 2013. 2013. p. 122-125. 6679654. (2013 IEEE Biomedical Circuits and Systems Conference, BioCAS 2013). https://doi.org/10.1109/BioCAS.2013.6679654