Non-labeled virus detection using inverted triangular Au nano-cavities arrayed as SERS-active substrate

Chia Wei Chang, Jiunn Der Liao, Ai Li Shiau, Chih Kai Yao

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


Virus detection is frequently based on antibody-based arrays and polymerase chain reactions. However, these methodologies have time-consuming incubation steps and obtaining clearly isolated target species is a complex process. In the present study, inverted triangular Au nano-cavities with various indentation depths and tip-to-tip displacements are well arrayed as a substrate for qualitative virus detection. The substrate is competent to entrap size-comparable target virus into nano-cavities, which as one, exerts its activity to form surface-enhanced Raman scattering particularly by the edges and cavities of the substrate. Through the induction of the electromagnetic effect by the substrate, the virus can be distinguished from the amino acids on its surface. The detectable concentration for encephalomyocarditis virus or adenovirus is 106 PFU/ml and that for influenza virus is 10 4 PFU/ml. The tailored substrate is enabled for fast-screening detection of target virus.

Original languageEnglish
Pages (from-to)471-478
Number of pages8
JournalSensors and Actuators, B: Chemical
Issue number1
Publication statusPublished - 2011 Aug 10

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry

Fingerprint Dive into the research topics of 'Non-labeled virus detection using inverted triangular Au nano-cavities arrayed as SERS-active substrate'. Together they form a unique fingerprint.

Cite this