TY - JOUR
T1 - Non-thermal reactive n2/he plasma exposure to inhibit epithelial head and neck tumor cells
AU - Wu, Chih Ying
AU - Liao, Jiunn Der
AU - Chen, Chang Han
AU - Lee, Han
AU - Wang, Shyh Hau
AU - Liu, Bernard Haochih
AU - Lee, Cheng Yi
AU - Shao, Pei Lin
AU - Li, Enya
N1 - Funding Information:
Funding: This research was funded by Ministry of Science and Technology of Taiwan, grant numbers: MOST 108-2218-E-006-054-MY3 and MOST 109-2811-E-006-531-MY2—and the APC was funded by MOST 108-2218-E-006-054-MY3.
Funding Information:
Acknowledgments: This work was supported by the Ministry of Science and Technology of Taiwan (grant number: MOST 108-2218-E-006-054-MY3 and 109-2811-E-006-531-MY2). The funder had no role in study design, data collection, and analysis, decision to publish, or preparation of the manuscript.
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/11
Y1 - 2021/11
N2 - The traditional therapy for head and neck cancer patients has several side effects. Hence, regular follow-up care is usually required. Recently, non-thermal micro-plasma was applied to inactivate cancer cells. Such a physical method provides localized energy and reactive oxygen/nitrogen species (ROS/RNS). In this study, the ability of non-oxygen N2/He micro-plasma to inactivate four pharynx squamous carcinomatous cells, namely SAS, CAL 27, FaDu, and Detroit 562, under different exposure durations is evaluated. The four cell lines were affected with regard to proliferation, reduction, and apoptosis-related DNA damage, implying that the cell medium is critical in plasma–cell interaction. This is expected to be a promising method for head and neck cancer cell suppression through plasma-initiated ROS/RNS species under a suitable exposure time.
AB - The traditional therapy for head and neck cancer patients has several side effects. Hence, regular follow-up care is usually required. Recently, non-thermal micro-plasma was applied to inactivate cancer cells. Such a physical method provides localized energy and reactive oxygen/nitrogen species (ROS/RNS). In this study, the ability of non-oxygen N2/He micro-plasma to inactivate four pharynx squamous carcinomatous cells, namely SAS, CAL 27, FaDu, and Detroit 562, under different exposure durations is evaluated. The four cell lines were affected with regard to proliferation, reduction, and apoptosis-related DNA damage, implying that the cell medium is critical in plasma–cell interaction. This is expected to be a promising method for head and neck cancer cell suppression through plasma-initiated ROS/RNS species under a suitable exposure time.
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U2 - 10.3390/coatings11111284
DO - 10.3390/coatings11111284
M3 - Article
AN - SCOPUS:85118328883
SN - 2079-6412
VL - 11
JO - Coatings
JF - Coatings
IS - 11
M1 - 1284
ER -