Non-typhoidal Salmonella bacteraemia in elderly patients: An increased risk for endovascular infections, osteomyelitis and mortality

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Abstract

Non-typhoidal Salmonella (NTS) is a common pathogen causing foodborne infections, bacteraemia, and extra-intestinal focal infections (EFIs) in humans. The study compares the clinical characteristics of elderly patients with NTS bacteraemia with those of young adults. Of 272 adults with NTS bacteraemia identified in this study, 162 (596%) were aged ?55 years. EFIs were observed in 36% of the 162 patients. The most common EFIs in the elderly patients (?55 years) was mycotic aneurysm, followed by pulmonary infections and bone/joint infections. Elderly patients more often had chronic heart, lung, renal and malignant diseases, had more EFIs, and a higher 30-day mortality rate. Independent factors of 30-day mortality in elderly patients were solid-organ tumour [adjusted odds ratio (aOR) 44, P=0003], mycotic aneurysm (aOR 37, P=0023) and shock (aOR 121, P<00001). HIV infection, autoimmune diseases, and receipt of immunosuppressive therapy were more often observed in young patients.

Original languageEnglish
Pages (from-to)2037-2044
Number of pages8
JournalEpidemiology and Infection
Volume140
Issue number11
DOIs
Publication statusPublished - 2012 Nov 1

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Osteomyelitis
Bacteremia
Salmonella
Focal Infection
Mortality
Infection
Infected Aneurysm
Odds Ratio
Lung
Immunosuppressive Agents
Autoimmune Diseases
HIV Infections
Young Adult
Shock
Joints
Kidney
Bone and Bones
Neoplasms

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Infectious Diseases

Cite this

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title = "Non-typhoidal Salmonella bacteraemia in elderly patients: An increased risk for endovascular infections, osteomyelitis and mortality",
abstract = "Non-typhoidal Salmonella (NTS) is a common pathogen causing foodborne infections, bacteraemia, and extra-intestinal focal infections (EFIs) in humans. The study compares the clinical characteristics of elderly patients with NTS bacteraemia with those of young adults. Of 272 adults with NTS bacteraemia identified in this study, 162 (596{\%}) were aged ?55 years. EFIs were observed in 36{\%} of the 162 patients. The most common EFIs in the elderly patients (?55 years) was mycotic aneurysm, followed by pulmonary infections and bone/joint infections. Elderly patients more often had chronic heart, lung, renal and malignant diseases, had more EFIs, and a higher 30-day mortality rate. Independent factors of 30-day mortality in elderly patients were solid-organ tumour [adjusted odds ratio (aOR) 44, P=0003], mycotic aneurysm (aOR 37, P=0023) and shock (aOR 121, P<00001). HIV infection, autoimmune diseases, and receipt of immunosuppressive therapy were more often observed in young patients.",
author = "Po-Lin Chen and Lee, {H. C.} and Nan-Yao Lee and Wu, {C. J.} and Sheng-Hsiang Lin and Hsin-I Shih and Lee, {C. C.} and Wen-Chien Ko and Chia-Ming Chang",
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AU - Wu, C. J.

AU - Lin, Sheng-Hsiang

AU - Shih, Hsin-I

AU - Lee, C. C.

AU - Ko, Wen-Chien

AU - Chang, Chia-Ming

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N2 - Non-typhoidal Salmonella (NTS) is a common pathogen causing foodborne infections, bacteraemia, and extra-intestinal focal infections (EFIs) in humans. The study compares the clinical characteristics of elderly patients with NTS bacteraemia with those of young adults. Of 272 adults with NTS bacteraemia identified in this study, 162 (596%) were aged ?55 years. EFIs were observed in 36% of the 162 patients. The most common EFIs in the elderly patients (?55 years) was mycotic aneurysm, followed by pulmonary infections and bone/joint infections. Elderly patients more often had chronic heart, lung, renal and malignant diseases, had more EFIs, and a higher 30-day mortality rate. Independent factors of 30-day mortality in elderly patients were solid-organ tumour [adjusted odds ratio (aOR) 44, P=0003], mycotic aneurysm (aOR 37, P=0023) and shock (aOR 121, P<00001). HIV infection, autoimmune diseases, and receipt of immunosuppressive therapy were more often observed in young patients.

AB - Non-typhoidal Salmonella (NTS) is a common pathogen causing foodborne infections, bacteraemia, and extra-intestinal focal infections (EFIs) in humans. The study compares the clinical characteristics of elderly patients with NTS bacteraemia with those of young adults. Of 272 adults with NTS bacteraemia identified in this study, 162 (596%) were aged ?55 years. EFIs were observed in 36% of the 162 patients. The most common EFIs in the elderly patients (?55 years) was mycotic aneurysm, followed by pulmonary infections and bone/joint infections. Elderly patients more often had chronic heart, lung, renal and malignant diseases, had more EFIs, and a higher 30-day mortality rate. Independent factors of 30-day mortality in elderly patients were solid-organ tumour [adjusted odds ratio (aOR) 44, P=0003], mycotic aneurysm (aOR 37, P=0023) and shock (aOR 121, P<00001). HIV infection, autoimmune diseases, and receipt of immunosuppressive therapy were more often observed in young patients.

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