Noninvasive transcutaneous bilirubin assessment of neonates with hyperbilirubinemia using a photon diffusion theory-based method

Nan Yu Cheng, Yi Ling Lin, Ming Chien Fang, Wen Hsien Lu, Chin Chieh Yang, Sheng Hao Tseng

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Transcutaneous bilirubinometers are widely used to screen neonatal jaundice. However, it was reported that their accuracy is compromised at low and high bilirubin levels. We used a photon diffusion theory-based method valid in the 450–600 nm wavelength region to overcome this obstacle. Our clinical study results showed that our system could properly determine the transcutaneous bilirubin concentrations at total serum bilirubin levels higher than 14 mg/dL, where a commercial bilirubinometer failed to provide proper results in several cases. These findings suggested that photon diffusion theory could be employed to improve the core algorithm of modern bilirubinometers and enhance their applicability.

Original languageEnglish
Pages (from-to)2969-2984
Number of pages16
JournalBiomedical Optics Express
Volume10
Issue number6
DOIs
Publication statusPublished - 2019 Jun 1

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

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