Nonlinear conductance-volume relationship for murine conductance catheter measurement system

Chia Ling Wei, Jonathan W. Valvano, Marc D. Feldman, John A. Pearce

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

The conductance catheter system is a tool to determine instantaneous left ventricular volume in vivo by converting measured conductance to volume. The currently adopted conductance-to-volume conversion equation was proposed by Baan, and the accuracy of this equation is limited by the assumption of a linear conductance-volume relationship. The electric field generated by a conductance catheter is nonuniform, which results in a nonlinear relationship between conductance and volume. This paper investigates this nonlinear relationship and proposes a new nonlinear conductance-to-volume conversion equation. The proposed nonlinear equation uses a single empirically determined calibration coefficient, derived from independently measured stroke volume. In vitro experiments and numerical model simulations were performed to verify and validate the proposed equation.

Original languageEnglish
Pages (from-to)1654-1661
Number of pages8
JournalIEEE Transactions on Biomedical Engineering
Volume52
Issue number10
DOIs
Publication statusPublished - 2005 Oct 1

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering

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