Nontyphoidal Salmonella bacteremia in patients with connective tissue diseases

Chien Fang Huang, Po Lin Chen, Ming Fei Liu, Ching Chi Lee, Nan Yao Lee, Chia Ming Chang, Hsin Chun Lee, Chi Jung Wu, Wen Chien Ko

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14 Citations (Scopus)

Abstract

Background/Purpose: Nontyphoidal Salmonella (NTS) is a crucial pathogen in immunocompromised patients, especially those with connective tissue disease (CTD) and corticosteroid or immunosuppressant therapy. The aim of this study is to identify the clinical characteristics and outcomes of patients with CTD and NTS bacteremia, and the clinical variations between systemic lupus erythematosus (SLE) and other CTDs. Methods: During a 15-year study period, from 1994 to 2009, NTS bacteremia patients were reviewed from the database of clinical microbiology laboratory. Medical records were reviewed for clinical information and only patients with underlying CTD were included. Results: From 1994 to 2009, there were 299 patients with NTS bacteremia. Forty-six (15.4%) patients had certain connective tissue diseases, and SLE was the major CTD, accounting for 73.9% (34) of 46 patients. In comparison with patients without CTD, the patients with CTD were younger (p<. 0.0001), had a predominance of female gender (p<. 0.0001), fewer extra-intestinal focal infections (p= 0.011), and a lower mortality rate (p= 0.008). Overall, there were four fatal cases, accounting for a mortality rate of 8.7% of those afflicted with CTD. The factors of old age (p<. 0.006), shock at presentation (p= 0.033), acute renal failure (p= 0.001), and presence of any extra-intestinal focal infection (p<. 0.0001) were associated with mortality in the univariate analysis. Conclusion: Nontyphoidal Salmonella bacteremia causes substantial morbidity and mortality in patients with connective tissue disease, especially in the elderly population. The aggressive detection of extra-intestinal infections may be beneficial.

Original languageEnglish
Pages (from-to)350-355
Number of pages6
JournalJournal of Microbiology, Immunology and Infection
Volume45
Issue number5
DOIs
Publication statusPublished - 2012 Oct

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases

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