Nontyphoidal Salmonella bacteremia in patients with connective tissue diseases

Chien Fang Huang, Po-Lin Chen, Ming-Fei Liu, Ching Chi Lee, Nan-Yao Lee, Chia-Ming Chang, Hsin Chun Lee, Chi Jung Wu, Wen-Chien Ko

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background/Purpose: Nontyphoidal Salmonella (NTS) is a crucial pathogen in immunocompromised patients, especially those with connective tissue disease (CTD) and corticosteroid or immunosuppressant therapy. The aim of this study is to identify the clinical characteristics and outcomes of patients with CTD and NTS bacteremia, and the clinical variations between systemic lupus erythematosus (SLE) and other CTDs. Methods: During a 15-year study period, from 1994 to 2009, NTS bacteremia patients were reviewed from the database of clinical microbiology laboratory. Medical records were reviewed for clinical information and only patients with underlying CTD were included. Results: From 1994 to 2009, there were 299 patients with NTS bacteremia. Forty-six (15.4%) patients had certain connective tissue diseases, and SLE was the major CTD, accounting for 73.9% (34) of 46 patients. In comparison with patients without CTD, the patients with CTD were younger (p<. 0.0001), had a predominance of female gender (p<. 0.0001), fewer extra-intestinal focal infections (p= 0.011), and a lower mortality rate (p= 0.008). Overall, there were four fatal cases, accounting for a mortality rate of 8.7% of those afflicted with CTD. The factors of old age (p<. 0.006), shock at presentation (p= 0.033), acute renal failure (p= 0.001), and presence of any extra-intestinal focal infection (p<. 0.0001) were associated with mortality in the univariate analysis. Conclusion: Nontyphoidal Salmonella bacteremia causes substantial morbidity and mortality in patients with connective tissue disease, especially in the elderly population. The aggressive detection of extra-intestinal infections may be beneficial.

Original languageEnglish
Pages (from-to)350-355
Number of pages6
JournalJournal of Microbiology, Immunology and Infection
Volume45
Issue number5
DOIs
Publication statusPublished - 2012 Oct 1

Fingerprint

Connective Tissue Diseases
Bacteremia
Salmonella
Focal Infection
Mortality
Systemic Lupus Erythematosus
Age Factors
Immunocompromised Host
Immunosuppressive Agents
Microbiology
Acute Kidney Injury
Medical Records
Shock
Adrenal Cortex Hormones
Databases
Morbidity

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Huang, Chien Fang ; Chen, Po-Lin ; Liu, Ming-Fei ; Lee, Ching Chi ; Lee, Nan-Yao ; Chang, Chia-Ming ; Lee, Hsin Chun ; Wu, Chi Jung ; Ko, Wen-Chien. / Nontyphoidal Salmonella bacteremia in patients with connective tissue diseases. In: Journal of Microbiology, Immunology and Infection. 2012 ; Vol. 45, No. 5. pp. 350-355.
@article{039985c00c494ab6bcbcfa5c9df17be0,
title = "Nontyphoidal Salmonella bacteremia in patients with connective tissue diseases",
abstract = "Background/Purpose: Nontyphoidal Salmonella (NTS) is a crucial pathogen in immunocompromised patients, especially those with connective tissue disease (CTD) and corticosteroid or immunosuppressant therapy. The aim of this study is to identify the clinical characteristics and outcomes of patients with CTD and NTS bacteremia, and the clinical variations between systemic lupus erythematosus (SLE) and other CTDs. Methods: During a 15-year study period, from 1994 to 2009, NTS bacteremia patients were reviewed from the database of clinical microbiology laboratory. Medical records were reviewed for clinical information and only patients with underlying CTD were included. Results: From 1994 to 2009, there were 299 patients with NTS bacteremia. Forty-six (15.4{\%}) patients had certain connective tissue diseases, and SLE was the major CTD, accounting for 73.9{\%} (34) of 46 patients. In comparison with patients without CTD, the patients with CTD were younger (p<. 0.0001), had a predominance of female gender (p<. 0.0001), fewer extra-intestinal focal infections (p= 0.011), and a lower mortality rate (p= 0.008). Overall, there were four fatal cases, accounting for a mortality rate of 8.7{\%} of those afflicted with CTD. The factors of old age (p<. 0.006), shock at presentation (p= 0.033), acute renal failure (p= 0.001), and presence of any extra-intestinal focal infection (p<. 0.0001) were associated with mortality in the univariate analysis. Conclusion: Nontyphoidal Salmonella bacteremia causes substantial morbidity and mortality in patients with connective tissue disease, especially in the elderly population. The aggressive detection of extra-intestinal infections may be beneficial.",
author = "Huang, {Chien Fang} and Po-Lin Chen and Ming-Fei Liu and Lee, {Ching Chi} and Nan-Yao Lee and Chia-Ming Chang and Lee, {Hsin Chun} and Wu, {Chi Jung} and Wen-Chien Ko",
year = "2012",
month = "10",
day = "1",
doi = "10.1016/j.jmii.2011.12.013",
language = "English",
volume = "45",
pages = "350--355",
journal = "Journal of Microbiology, Immunology and Infection",
issn = "1684-1182",
publisher = "Elsevier Taiwan LLC",
number = "5",

}

Nontyphoidal Salmonella bacteremia in patients with connective tissue diseases. / Huang, Chien Fang; Chen, Po-Lin; Liu, Ming-Fei; Lee, Ching Chi; Lee, Nan-Yao; Chang, Chia-Ming; Lee, Hsin Chun; Wu, Chi Jung; Ko, Wen-Chien.

In: Journal of Microbiology, Immunology and Infection, Vol. 45, No. 5, 01.10.2012, p. 350-355.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Nontyphoidal Salmonella bacteremia in patients with connective tissue diseases

AU - Huang, Chien Fang

AU - Chen, Po-Lin

AU - Liu, Ming-Fei

AU - Lee, Ching Chi

AU - Lee, Nan-Yao

AU - Chang, Chia-Ming

AU - Lee, Hsin Chun

AU - Wu, Chi Jung

AU - Ko, Wen-Chien

PY - 2012/10/1

Y1 - 2012/10/1

N2 - Background/Purpose: Nontyphoidal Salmonella (NTS) is a crucial pathogen in immunocompromised patients, especially those with connective tissue disease (CTD) and corticosteroid or immunosuppressant therapy. The aim of this study is to identify the clinical characteristics and outcomes of patients with CTD and NTS bacteremia, and the clinical variations between systemic lupus erythematosus (SLE) and other CTDs. Methods: During a 15-year study period, from 1994 to 2009, NTS bacteremia patients were reviewed from the database of clinical microbiology laboratory. Medical records were reviewed for clinical information and only patients with underlying CTD were included. Results: From 1994 to 2009, there were 299 patients with NTS bacteremia. Forty-six (15.4%) patients had certain connective tissue diseases, and SLE was the major CTD, accounting for 73.9% (34) of 46 patients. In comparison with patients without CTD, the patients with CTD were younger (p<. 0.0001), had a predominance of female gender (p<. 0.0001), fewer extra-intestinal focal infections (p= 0.011), and a lower mortality rate (p= 0.008). Overall, there were four fatal cases, accounting for a mortality rate of 8.7% of those afflicted with CTD. The factors of old age (p<. 0.006), shock at presentation (p= 0.033), acute renal failure (p= 0.001), and presence of any extra-intestinal focal infection (p<. 0.0001) were associated with mortality in the univariate analysis. Conclusion: Nontyphoidal Salmonella bacteremia causes substantial morbidity and mortality in patients with connective tissue disease, especially in the elderly population. The aggressive detection of extra-intestinal infections may be beneficial.

AB - Background/Purpose: Nontyphoidal Salmonella (NTS) is a crucial pathogen in immunocompromised patients, especially those with connective tissue disease (CTD) and corticosteroid or immunosuppressant therapy. The aim of this study is to identify the clinical characteristics and outcomes of patients with CTD and NTS bacteremia, and the clinical variations between systemic lupus erythematosus (SLE) and other CTDs. Methods: During a 15-year study period, from 1994 to 2009, NTS bacteremia patients were reviewed from the database of clinical microbiology laboratory. Medical records were reviewed for clinical information and only patients with underlying CTD were included. Results: From 1994 to 2009, there were 299 patients with NTS bacteremia. Forty-six (15.4%) patients had certain connective tissue diseases, and SLE was the major CTD, accounting for 73.9% (34) of 46 patients. In comparison with patients without CTD, the patients with CTD were younger (p<. 0.0001), had a predominance of female gender (p<. 0.0001), fewer extra-intestinal focal infections (p= 0.011), and a lower mortality rate (p= 0.008). Overall, there were four fatal cases, accounting for a mortality rate of 8.7% of those afflicted with CTD. The factors of old age (p<. 0.006), shock at presentation (p= 0.033), acute renal failure (p= 0.001), and presence of any extra-intestinal focal infection (p<. 0.0001) were associated with mortality in the univariate analysis. Conclusion: Nontyphoidal Salmonella bacteremia causes substantial morbidity and mortality in patients with connective tissue disease, especially in the elderly population. The aggressive detection of extra-intestinal infections may be beneficial.

UR - http://www.scopus.com/inward/record.url?scp=84866627318&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84866627318&partnerID=8YFLogxK

U2 - 10.1016/j.jmii.2011.12.013

DO - 10.1016/j.jmii.2011.12.013

M3 - Article

C2 - 22571997

AN - SCOPUS:84866627318

VL - 45

SP - 350

EP - 355

JO - Journal of Microbiology, Immunology and Infection

JF - Journal of Microbiology, Immunology and Infection

SN - 1684-1182

IS - 5

ER -