A hypothetical pharmacophore of 5α-reductase inhibitors was generated and served as a template in virtual screening. When the pharmacophore was used, eight isoflavone derivatives were characterized as novel potential nonsteroidal inhibitors of rat 5α-reductase. This investigation has demonstrated a practical approach toward the development of lead compounds through a hypothetic pharmacophore via threedimensional database searching.
All Science Journal Classification (ASJC) codes
- Molecular Medicine
- Drug Discovery