Novel lead generation through hypothetical pharmacophore three-dimensional database searching: Discovery of isoflavonoids as nonsteroidal inhibitors of rat 5α-reductase

G. S. Chen, C. S. Chang, Wai-Ming Kan, C. L. Chang, K. C. Wang, J. W. Chern

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

A hypothetical pharmacophore of 5α-reductase inhibitors was generated and served as a template in virtual screening. When the pharmacophore was used, eight isoflavone derivatives were characterized as novel potential nonsteroidal inhibitors of rat 5α-reductase. This investigation has demonstrated a practical approach toward the development of lead compounds through a hypothetic pharmacophore via threedimensional database searching.

Original languageEnglish
Pages (from-to)3759-3763
Number of pages5
JournalJournal of Medicinal Chemistry
Volume44
Issue number23
DOIs
Publication statusPublished - 2001 Nov 8

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery

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