Novel magnetic/ultrasound focusing system enhances nanoparticle drug delivery for glioma treatment

Pin Yuan Chen, Hao Li Liu, Mu Yi Hua, Hung Wei Yang, Chiung Yin Huang, Po Chun Chu, Lee Ang Lyu, I. Chou Tseng, Li Ying Feng, Hong Chieh Tsai, Shu Mei Chen, Yu Jen Lu, Jiun Jie Wang, Tzu Chen Yen, Yunn Hwa Ma, Tony Wu, Jyh Ping Chen, Jih Ing Chuang, Jyh Wei Shin, Chuen HsuehKuo Chen Wei

Research output: Contribution to journalArticlepeer-review

96 Citations (Scopus)

Abstract

Malignant glioma is a common and severe primary brain tumor with a high recurrence rate and an extremely high mortality rate within 2 years of diagnosis, even when surgical, radiological, and chemotherapeutic interventions are applied. Intravenously administered drugs have limited use because of their adverse systemic effects and poor blood-brain barrier penetration. Here, we combine 2 methods to increase drug delivery to brain tumors. Focused ultrasound transiently permeabilizes the blood-brain barrier, increasing passive diffusion. Subsequent application of an external magnetic field then actively enhances localization of a chemotherapeutic agent immobilized on a novel magnetic nanoparticle. Combining these techniques significantly improved the delivery of 1,3-bis(2-chloroethyl)-1- nitrosourea to rodent gliomas. Furthermore, the physicochemical properties of the nanoparticles allowed their delivery to be monitored by magnetic resonance imaging (MRI). The resulting suppression of tumor progression without damaging the normal regions of the brain was verified by MRI and histological examination. This noninvasive, reversible technique promises to provide a more effective and tolerable means of tumor treatment, with lower therapeutic doses and concurrent clinical monitoring.

Original languageEnglish
Pages (from-to)1050-1060
Number of pages11
JournalNeuro-Oncology
Volume12
Issue number10
DOIs
Publication statusPublished - 2010 Oct

All Science Journal Classification (ASJC) codes

  • Oncology
  • Clinical Neurology
  • Cancer Research

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