Novel synthesis of α-PNA monomers by U-4CR

P. C. Huang, G. J. Hsu, B. R. Zhuang, Kuang-Sen Sung

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6 Citations (Scopus)


A novel synthesis of α-PNA monomers was carried out by U-4CR, followed by photochemical cleavage of the 2-nitrobenzyl group and selective hydrolysis in the presence of 10% HCl in THF. Three of four functional components in the U-4CR were specially protected: cyclohexenyl isocyanide, Boc for protecting the amino group of glycine, and 2-nitrobenzyl group as a photocage (photoremovable protecting group) for ammonia. The amino group of aldehyde-containing adenine is too weak to interfere with the U-4CR, so that it is not necessary to be protected.

Original languageEnglish
Pages (from-to)449-453
Number of pages5
JournalAmino Acids
Issue number3
Publication statusPublished - 2008 Apr 1

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Organic Chemistry


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