Novel synthesis of α-PNA monomers by U-4CR

P. C. Huang, G. J. Hsu, B. R. Zhuang, Kuang-Sen Sung

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A novel synthesis of α-PNA monomers was carried out by U-4CR, followed by photochemical cleavage of the 2-nitrobenzyl group and selective hydrolysis in the presence of 10% HCl in THF. Three of four functional components in the U-4CR were specially protected: cyclohexenyl isocyanide, Boc for protecting the amino group of glycine, and 2-nitrobenzyl group as a photocage (photoremovable protecting group) for ammonia. The amino group of aldehyde-containing adenine is too weak to interfere with the U-4CR, so that it is not necessary to be protected.

Original languageEnglish
Pages (from-to)449-453
Number of pages5
JournalAmino Acids
Volume34
Issue number3
DOIs
Publication statusPublished - 2008 Apr 1

Fingerprint

Cyanides
Adenine
Ammonia
Aldehydes
Glycine
Hydrolysis
Monomers

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology

Cite this

Huang, P. C. ; Hsu, G. J. ; Zhuang, B. R. ; Sung, Kuang-Sen. / Novel synthesis of α-PNA monomers by U-4CR. In: Amino Acids. 2008 ; Vol. 34, No. 3. pp. 449-453.
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Huang, PC, Hsu, GJ, Zhuang, BR & Sung, K-S 2008, 'Novel synthesis of α-PNA monomers by U-4CR', Amino Acids, vol. 34, no. 3, pp. 449-453. https://doi.org/10.1007/s00726-007-0548-6

Novel synthesis of α-PNA monomers by U-4CR. / Huang, P. C.; Hsu, G. J.; Zhuang, B. R.; Sung, Kuang-Sen.

In: Amino Acids, Vol. 34, No. 3, 01.04.2008, p. 449-453.

Research output: Contribution to journalArticle

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