Novel synthesis of α-PNA monomers by U-4CR

P. C. Huang; G. J. Hsu; B. R. Zhuang; Kuang-Sen Sung

doi:10.1007/s00726-007-0548-6

Novel synthesis of α-PNA monomers by U-4CR

P. C. Huang, G. J. Hsu, B. R. Zhuang, Kuang-Sen Sung

Department of Chemistry

Research output: Contribution to journal › Article

5 Citations (Scopus)

Abstract

A novel synthesis of α-PNA monomers was carried out by U-4CR, followed by photochemical cleavage of the 2-nitrobenzyl group and selective hydrolysis in the presence of 10% HCl in THF. Three of four functional components in the U-4CR were specially protected: cyclohexenyl isocyanide, Boc for protecting the amino group of glycine, and 2-nitrobenzyl group as a photocage (photoremovable protecting group) for ammonia. The amino group of aldehyde-containing adenine is too weak to interfere with the U-4CR, so that it is not necessary to be protected.

Original language	English
Pages (from-to)	449-453
Number of pages	5
Journal	Amino Acids
Volume	34
Issue number	3
DOIs	https://doi.org/10.1007/s00726-007-0548-6
Publication status	Published - 2008 Apr 1

All Science Journal Classification (ASJC) codes

Biochemistry
Clinical Biochemistry
Organic Chemistry

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AU - Huang, P. C.

AU - Hsu, G. J.

AU - Zhuang, B. R.

AU - Sung, Kuang-Sen

PY - 2008/4/1

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