Novel temperature based technique for measurement of endothelial dysfunction

Nachiket Kharalkar, Jonathan W. Valvano, Morteza Naghavi, Chia-Ling Wei

Research output: Contribution to journalConference article

4 Citations (Scopus)

Abstract

The endothelial cells, which form the inner lining of the arteries, respond to changes in pressure by producing nitric oxide (NO) which in turn causes vasodilation. The normal functioning of the endothelium is hampered in certain cardiovascular diseases. Various methods have been developed to non-invasively determine the endothelial dysfunction (EDF). We propose to measure the EDF by causing reactive hyperemia in the arm and measuring the temperature variations of the hand region. We created reactive hyperemia by occluding the arm by blood pressure cuff at about 200 mmHg for 5 minutes, and then suddenly released the pressure. Using a computer-based data acquisition system, the temperature variations of the distal palmer pad/middle finger, during the entire procedure were continuously monitored. Initial studies have indicated that there is significant increase in the rate of rise as compared to rate of fall of temperature (mean increase = 117%, standard deviation = 50%). Our goal is to non-invasively predict EDF from the temperature technique.

Original languageEnglish
Pages (from-to)308-311
Number of pages4
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume1
Publication statusPublished - 2003 Dec 1
EventA New Beginning for Human Health: Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Cancun, Mexico
Duration: 2003 Sep 172003 Sep 21

Fingerprint

Temperature
Hyperemia
Arm
Pressure
Endothelial cells
Blood pressure
Nitric oxide
Linings
Information Systems
Vasodilation
Fingers
Endothelium
Data acquisition
Nitric Oxide
Cardiovascular Diseases
Endothelial Cells
Hand
Arteries
Blood Pressure

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Cite this

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Novel temperature based technique for measurement of endothelial dysfunction. / Kharalkar, Nachiket; Valvano, Jonathan W.; Naghavi, Morteza; Wei, Chia-Ling.

In: Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, Vol. 1, 01.12.2003, p. 308-311.

Research output: Contribution to journalConference article

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AU - Kharalkar, Nachiket

AU - Valvano, Jonathan W.

AU - Naghavi, Morteza

AU - Wei, Chia-Ling

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AB - The endothelial cells, which form the inner lining of the arteries, respond to changes in pressure by producing nitric oxide (NO) which in turn causes vasodilation. The normal functioning of the endothelium is hampered in certain cardiovascular diseases. Various methods have been developed to non-invasively determine the endothelial dysfunction (EDF). We propose to measure the EDF by causing reactive hyperemia in the arm and measuring the temperature variations of the hand region. We created reactive hyperemia by occluding the arm by blood pressure cuff at about 200 mmHg for 5 minutes, and then suddenly released the pressure. Using a computer-based data acquisition system, the temperature variations of the distal palmer pad/middle finger, during the entire procedure were continuously monitored. Initial studies have indicated that there is significant increase in the rate of rise as compared to rate of fall of temperature (mean increase = 117%, standard deviation = 50%). Our goal is to non-invasively predict EDF from the temperature technique.

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