Novel terpenoids from Calocedrus macrolepis var. formosana

Chin Lin Hsieh, Mei Hwei Tseng, Ryh Nan Pan, Jang Yang Chang, Ching Chuan Kuo, Tzong Huei Lee, Yueh Hsiung Kuo

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Calocetriol (1), diacetylcalocediol (2), and ferrugimenthenol (3) were isolated from the bark of Calocedrus macrolepis var. formosana. Among them, 1 and 2 are secoabietane-type diterpenoids, and 3, with a novel C 20-C 10 skeleton, is classified as a meroterpenoid. The structures of 1-3 were elucidated by spectroscopic analyses, and their biological activities were also evaluated. Compound 3 exhibited significant cytotoxic activity against human oral epidermoid carcinoma KB cells with an IC 50 value of 9.0±0.1 μM.

Original languageEnglish
Pages (from-to)1901-1907
Number of pages7
JournalChemistry and Biodiversity
Volume8
Issue number10
DOIs
Publication statusPublished - 2011 Oct 1

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Cupressaceae
KB Cells
Diterpenes
Terpenes
Bioactivity
Skeleton
Human Activities
Squamous Cell Carcinoma

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Molecular Medicine
  • Molecular Biology

Cite this

Hsieh, C. L., Tseng, M. H., Pan, R. N., Chang, J. Y., Kuo, C. C., Lee, T. H., & Kuo, Y. H. (2011). Novel terpenoids from Calocedrus macrolepis var. formosana. Chemistry and Biodiversity, 8(10), 1901-1907. https://doi.org/10.1002/cbdv.201000237
Hsieh, Chin Lin ; Tseng, Mei Hwei ; Pan, Ryh Nan ; Chang, Jang Yang ; Kuo, Ching Chuan ; Lee, Tzong Huei ; Kuo, Yueh Hsiung. / Novel terpenoids from Calocedrus macrolepis var. formosana. In: Chemistry and Biodiversity. 2011 ; Vol. 8, No. 10. pp. 1901-1907.
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abstract = "Calocetriol (1), diacetylcalocediol (2), and ferrugimenthenol (3) were isolated from the bark of Calocedrus macrolepis var. formosana. Among them, 1 and 2 are secoabietane-type diterpenoids, and 3, with a novel C 20-C 10 skeleton, is classified as a meroterpenoid. The structures of 1-3 were elucidated by spectroscopic analyses, and their biological activities were also evaluated. Compound 3 exhibited significant cytotoxic activity against human oral epidermoid carcinoma KB cells with an IC 50 value of 9.0±0.1 μM.",
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Hsieh, CL, Tseng, MH, Pan, RN, Chang, JY, Kuo, CC, Lee, TH & Kuo, YH 2011, 'Novel terpenoids from Calocedrus macrolepis var. formosana', Chemistry and Biodiversity, vol. 8, no. 10, pp. 1901-1907. https://doi.org/10.1002/cbdv.201000237

Novel terpenoids from Calocedrus macrolepis var. formosana. / Hsieh, Chin Lin; Tseng, Mei Hwei; Pan, Ryh Nan; Chang, Jang Yang; Kuo, Ching Chuan; Lee, Tzong Huei; Kuo, Yueh Hsiung.

In: Chemistry and Biodiversity, Vol. 8, No. 10, 01.10.2011, p. 1901-1907.

Research output: Contribution to journalArticle

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AU - Lee, Tzong Huei

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