Novel terpenoids from Calocedrus macrolepis var. formosana

Chin Lin Hsieh, Mei Hwei Tseng, Ryh Nan Pan, Jang Yang Chang, Ching Chuan Kuo, Tzong Huei Lee, Yueh Hsiung Kuo

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Calocetriol (1), diacetylcalocediol (2), and ferrugimenthenol (3) were isolated from the bark of Calocedrus macrolepis var. formosana. Among them, 1 and 2 are secoabietane-type diterpenoids, and 3, with a novel C 20-C 10 skeleton, is classified as a meroterpenoid. The structures of 1-3 were elucidated by spectroscopic analyses, and their biological activities were also evaluated. Compound 3 exhibited significant cytotoxic activity against human oral epidermoid carcinoma KB cells with an IC 50 value of 9.0±0.1 μM.

Original languageEnglish
Pages (from-to)1901-1907
Number of pages7
JournalChemistry and Biodiversity
Volume8
Issue number10
DOIs
Publication statusPublished - 2011 Oct 1

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Molecular Medicine
  • Molecular Biology

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    Hsieh, C. L., Tseng, M. H., Pan, R. N., Chang, J. Y., Kuo, C. C., Lee, T. H., & Kuo, Y. H. (2011). Novel terpenoids from Calocedrus macrolepis var. formosana. Chemistry and Biodiversity, 8(10), 1901-1907. https://doi.org/10.1002/cbdv.201000237