NovelN-transfer reagent for converting α-amino acid derivatives to α-diazo compounds

Guan Han Lu, Tzu Chia Huang, Hsiao Chin Hsueh, Shin Cherng Yang, Ting Wei Cho, Ho Hsuan Chou

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

A novel universalN-transfer reagent for direct and effective transformation of α-amino ketones, acetamides, and esters to the corresponding α-diazo products under mild basic conditions has been developed. This one-step synthetic approach not only allows for generation of α-substituted-α-diazo carbonyl compounds from α-amino acid derivatives but also permits preparation of α-diazo dipeptides fromN-terminal dipeptides (32 examples, up to 91%).

Original languageEnglish
Pages (from-to)4839-4842
Number of pages4
JournalChemical Communications
Volume57
Issue number39
DOIs
Publication statusPublished - 2021 May 14

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • General Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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