Novelty seeking mediates the effect of DRD3 variation on onset age of amphetamine dependence in Han Chinese population

Shin Chang Kuo, Yi Wei Yeh, Chun Yen Chen, Chang Chih Huang, Tien Yu Chen, Che Hung Yen, Chih Sung Liang, Pei Shen Ho, Ru Band Lu, San Yuan Huang

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


The dopamine receptor D3 (DRD3) gene, one of the candidate genes for amphetamine dependence (AD), is involved in the mesolimbic dopaminergic system, implicated as the underlying mechanism of addiction. Our case–control study aimed to investigate whether the DRD3 gene is associated with the susceptibility to AD and specific personality traits in AD patients. A total of 1060 unrelated Han Chinese subjects (559 AD patients and 501 controls) were screened using the same assessment tool and genotyped for eight DRD3 polymorphisms. All patients met the DSM-IV-TR criteria for AD, and personality traits of 539 were assessed using a Tridimensional Personality Questionnaire. Furthermore, AD individuals were divided into four clinical subgroups based on gender and psychosis status, to reduce the clinical heterogeneity. We found that the ATA haplotype combination for SNPs rs324029, rs6280, and rs9825563, respectively, was significantly associated with total AD patients (p = 0.0003 after 10,000 permutations). Similar results were observed in the both male and non-psychosis subgroup but not in other subgroups. In addition, DRD3 rs9825563 may influence onset age of drug use, partially mediated by novelty seeking in the non-psychosis AD group. In conclusion, DRD3 is a potential genetic factor in the susceptibility to AD and is associated with onset age of drug use through interaction with novelty seeking in a specific patient group in the Han Chinese population.

Original languageEnglish
Pages (from-to)249-260
Number of pages12
JournalEuropean Archives of Psychiatry and Clinical Neuroscience
Issue number3
Publication statusPublished - 2018 Apr 1

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Pharmacology (medical)

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