Nuclear hormone receptors in podocytes

Simran Khurana, Leslie A. Bruggeman, Hung Ying Kao

Research output: Contribution to journalReview articlepeer-review

13 Citations (Scopus)

Abstract

Nuclear receptors are a family of ligand-activated, DNA sequence-specific transcription factors that regulate various aspects of animal development, cell proliferation, differentiation, and homeostasis. The physiological roles of nuclear receptors and their ligands have been intensively studied in cancer and metabolic syndrome. However, their role in kidney diseases is still evolving, despite their ligands being used clinically to treat renal diseases for decades. This review will discuss the progress of our understanding of the role of nuclear receptors and their ligands in kidney physiology with emphasis on their roles in treating glomerular disorders and podocyte injury repair responses.

Original languageEnglish
Article number33
JournalCell and Bioscience
Volume2
Issue number1
DOIs
Publication statusPublished - 2012 Sep 20

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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