Nuclear topology, epigenetics, and keratinocyte differentiation

Michael W. Hughes, Wange Lu, Cheng Ming Chuong

Research output: Contribution to journalComment/debatepeer-review


Recent progress in epigenetics reveals dynamic chromatin interactions in the nucleus during development, regeneration, reprogramming, and in disease. Higher-order chromatin organization is manifested as changes in the topological distribution of eu-/heterochromatin and in nuclear morphology. We are now able to gain new knowledge about these changes at the genomic level.

Original languageEnglish
Pages (from-to)2130-2133
Number of pages4
JournalJournal of Investigative Dermatology
Issue number9
Publication statusPublished - 2013 Sep

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology


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