NUCLEIC ACID CLEAVAGE COMPLEX AND METHOD FOR USING THE SAME

Dar-Bin Shieh (Inventor)

Research output: Patent

Abstract

A nucleic acid cleavage complex is disclosed, which includes: a nanoparticle, a nucleic acid cleavage reagent, and a polynucleotide chain specifically recognizing a sequence of a target nucleic acid and having a first terminal and a second terminal opposite to the first terminal, wherein the first terminal is connected to the nanoparticle, the second terminal is connected to the nucleic acid cleavage reagent,and the first terminal sequence and the second terminal sequence are base-paired to make the polynucleotide chain form a hairpin.
Original languageEnglish
Patent number8574893
Publication statusPublished - 2012 May 17

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Nucleic Acids
Polynucleotides
Nanoparticles

Cite this

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abstract = "A nucleic acid cleavage complex is disclosed, which includes: a nanoparticle, a nucleic acid cleavage reagent, and a polynucleotide chain specifically recognizing a sequence of a target nucleic acid and having a first terminal and a second terminal opposite to the first terminal, wherein the first terminal is connected to the nanoparticle, the second terminal is connected to the nucleic acid cleavage reagent,and the first terminal sequence and the second terminal sequence are base-paired to make the polynucleotide chain form a hairpin.",
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AB - A nucleic acid cleavage complex is disclosed, which includes: a nanoparticle, a nucleic acid cleavage reagent, and a polynucleotide chain specifically recognizing a sequence of a target nucleic acid and having a first terminal and a second terminal opposite to the first terminal, wherein the first terminal is connected to the nanoparticle, the second terminal is connected to the nucleic acid cleavage reagent,and the first terminal sequence and the second terminal sequence are base-paired to make the polynucleotide chain form a hairpin.

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