Numerical Analysis and Experimental Estimation of a Low-Leakage Injection Technique for Capillary Electrophoresis

Lung Ming Fu, Che Hsin Lin

Research output: Contribution to journalArticlepeer-review

50 Citations (Scopus)

Abstract

This paper presents an experimental and numerical investigation into the use of low-leakage injection techniques to deliver sample plugs within electrophoresis microchips. The study addresses the principal material transport mechanisms such as electrokinetic migration, fluid flow, and diffusion and gives detail analyses to the double-L injection technique, which employs electrokinetic manipulations to avoid sample leakage within the microchip. Electrical potential contour, velocity vector, and streamline distribution in the micro CE chip are successfully developed. Experimental and numerical testing results show the double-L injection technique is capable of reducing sample leakage within cross-form microfluidic chips. The current study confirms the double-L injection technique has an exciting potential for use in high-quality, high-throughput chemical analysis applications and in many other applications throughout the field of micro total analysis systems.

Original languageEnglish
Pages (from-to)5790-5796
Number of pages7
JournalAnalytical chemistry
Volume75
Issue number21
DOIs
Publication statusPublished - 2003 Nov 1

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry

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