TY - JOUR
T1 - Obstructive sleep apnea among HIV-infected men in the highly active antiretroviral therapy era
T2 - a nation-wide longitudinal cohort study in Taiwan, 2000–2011
AU - Chen, Yen Chin
AU - Lin, Cheng Yu
AU - Li, Chung Yi
AU - Zhang, Yingze
AU - Ko, Wen Chien
AU - Ko, Nai Ying
N1 - Funding Information:
This study was based in part on the data from the National Health Insurance Research Database, which was provided by the Bureau of National Health Insurance, Department of Health and managed by the National Health Research Institutes. The interpretations and conclusions contained herein do not represent those of the Bureau of National Health Insurance, Department of Health or the National Health Research Institutes.
Funding Information:
This work was supported by the Ministry of Science and Technology, Executive Yuan of Taiwan , Taiwan ( MOST 105-3011-E-006-002 ) and Medical Device Innovation Center , National Cheng Kung University, Taiwan .
Funding Information:
This work was supported by the Ministry of Science and Technology, Executive Yuan of Taiwan, Taiwan (MOST 105-3011-E-006-002) and Medical Device Innovation Center, National Cheng Kung University, Taiwan.
Publisher Copyright:
© 2019
PY - 2020/1
Y1 - 2020/1
N2 - Objectives: This study compared the incidence of obstructive sleep apnea (OSA) between HIV-infected and matched non-infected persons and aimed to determine the effect of highly active antiretroviral therapy (HAART) on the incidence of OSA among HIV-infected men. Methods: A population-based cohort design was conducted using the National Health Insurance Research Database (NHIRD), which contained 13,552 HIV-infected persons and 134,361 matched age-, sex-, and index year-controls. The incidence density rates (IRR) were calculated to estimate the OSA incidence both in the HIV group and matched controls. Cox proportional hazard models were applied to assess the HAART effect on the incidence of OSA among HIV-infected men. Results: The IRR of OSA was lower in the HIV group than in the matched controls (1.91 vs. 2.26 per 1000 person-years, respectively). The associated factors for OSA in HIV-infected men were higher monthly salary (adjusted hazard ratio [aHR], 1.97, p < 0.01), obesity (aHR, 3.99, p < 0.01), and chronic obstructive pulmonary disease (aHR, 2.02, p < 0.01). Continued HAART at least a half year was associated with less diagnosed OSA (AHR, 0.70, p = 0.03) in HIV-infected men. Conclusions: HIV-infected persons had a lower rate of OSA diagnosis compared to the matched controls. Healthcare providers are needed to increase awareness in HIV-infected men with sleep disorders, especially for those with low social economic status, comorbidities, and non-continuous HAART use.
AB - Objectives: This study compared the incidence of obstructive sleep apnea (OSA) between HIV-infected and matched non-infected persons and aimed to determine the effect of highly active antiretroviral therapy (HAART) on the incidence of OSA among HIV-infected men. Methods: A population-based cohort design was conducted using the National Health Insurance Research Database (NHIRD), which contained 13,552 HIV-infected persons and 134,361 matched age-, sex-, and index year-controls. The incidence density rates (IRR) were calculated to estimate the OSA incidence both in the HIV group and matched controls. Cox proportional hazard models were applied to assess the HAART effect on the incidence of OSA among HIV-infected men. Results: The IRR of OSA was lower in the HIV group than in the matched controls (1.91 vs. 2.26 per 1000 person-years, respectively). The associated factors for OSA in HIV-infected men were higher monthly salary (adjusted hazard ratio [aHR], 1.97, p < 0.01), obesity (aHR, 3.99, p < 0.01), and chronic obstructive pulmonary disease (aHR, 2.02, p < 0.01). Continued HAART at least a half year was associated with less diagnosed OSA (AHR, 0.70, p = 0.03) in HIV-infected men. Conclusions: HIV-infected persons had a lower rate of OSA diagnosis compared to the matched controls. Healthcare providers are needed to increase awareness in HIV-infected men with sleep disorders, especially for those with low social economic status, comorbidities, and non-continuous HAART use.
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U2 - 10.1016/j.sleep.2019.07.011
DO - 10.1016/j.sleep.2019.07.011
M3 - Article
C2 - 31739231
AN - SCOPUS:85074885993
VL - 65
SP - 89
EP - 95
JO - Sleep Medicine
JF - Sleep Medicine
SN - 1389-9457
ER -
