Obstructive sleep apnea in children and adolescents and the risk of major adverse cardiovascular events: A nationwide cohort study in Taiwan

Nian Sheng Tzeng, Chi Hsiang Chung, Hsin An Chang, Chuan Chia Chang, Ru Band Lu, Hui Wen Yeh, Wei Shan Chiang, Yu Chen Kao, Shan Yueh Chang, Wu Chien Chien

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Study Objectives: This study has investigated the risk of major adverse cardiovascular events (MACEs), including acute myocardial infarction, coronary artery disease, peripheral artery disease, and acute stroke, among children and adolescents (age younger than 20 years) with obstructive sleep apnea (OSA). Methods: In this study, the population-based National Health Insurance Research Database of Taiwan was used to identify patients in whom OSA had been frst diagnosed between 2000 and 2015. Children and adolescents with OSA (n = 6,535) were included with 1:3 ratio by age, sex, and index year of control participants without OSA (n = 19,605). The Cox proportional regression model was used to evaluate the risk of MACEs in this cohort study. Results: After a 15-year follow-up, the incidence rate of MACEs was higher in the OSA cohort when compared with the non-OSA control cohort (15.97 and 8.20 per 100,000 person-years, respectively). After adjusting for covariates, the risk of MACEs among children and adolescents with OSA was still signifcantly higher (hazard ratio = 2.050; 95% confdence interval = 1.312 3.107; P = .010). No MACEs were found in the children and adolescents with OSA who received continuous airway positive pressure treatment or pharyngeal surgery. Conclusions: This study found a signifcantly higher risk of MACEs in children and adolescents with OSA. These fndings strongly suggest that clinicians should provide careful follow-up and medical treatment for children and adolescents with OSA.

Original languageEnglish
Pages (from-to)275-283
Number of pages9
JournalJournal of Clinical Sleep Medicine
Volume15
Issue number2
DOIs
Publication statusPublished - 2019

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Obstructive sleep apnea in children and adolescents and the risk of major adverse cardiovascular events: A nationwide cohort study in Taiwan'. Together they form a unique fingerprint.

Cite this