Occurrence of xenobiotic ligands for retinoid X receptors and thyroid hormone receptors in the aquatic environment of Taiwan

Chien Hsun Chen, Pei Hsin Chou, Masanobu Kawanishi, Takashi Yagi

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Various synthetic compounds are frequently discharged into the environment via human activities. Among them, certain contaminants may disrupt normal physiological functions of wildlife and humans via interactions with nuclear receptors. To protect human health and the environment, it is important to detect environmental ligands for human nuclear receptors. In this study, yeast-based reporter gene assays were used to investigate the occurrence of xenobiotic ligands for retinoid X receptors (RXR) and thyroid hormone receptors (TR) in the aquatic environment of Taiwan. Experimental results revealed that RXR agonist/antagonist activity was detected in river water and sediment samples. In particular, high RXR agonist/antagonist activity was found in the samples collected near river mouths. Additionally, few samples also elicited significant TR antagonist activity. Our findings show that the aquatic environment of Taiwan was contaminated with RXR and TR ligands. Further study is necessary to identify these xenobiotic RXR and TR agonists and antagonists.

Original languageEnglish
Pages (from-to)613-618
Number of pages6
JournalMarine Pollution Bulletin
Volume85
Issue number2
DOIs
Publication statusPublished - 2014 Aug 30

All Science Journal Classification (ASJC) codes

  • Oceanography
  • Aquatic Science
  • Pollution

Fingerprint Dive into the research topics of 'Occurrence of xenobiotic ligands for retinoid X receptors and thyroid hormone receptors in the aquatic environment of Taiwan'. Together they form a unique fingerprint.

Cite this