On-Chip HbA1C detection utlizing a compact surface pla-smon grating sensor integrated on a microfldic system

Ko Wei Chang, Huan Ting Chou, Ching Hsuan Yang, Shu Chu Shiesh, Ming Chang Lee, Gwo Bin Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Diabetes mellitus may cause serious complications, including arteriosclerosis, heart disease and kidney failure, and therefore requires routine monitoring. Increasing evidences show that the concentration of glycated hemoglobin (HbA1c) can be utilized as a more reliable index for diagnosing and monitoring diabetes. In this study, we presented a new approach using HbA1c-specific aptamers as recognition molecules due to its high affinity and specificity. Moreover, a compact, grating-based surface plasmon resonance sensor incorporated with a microfluidic system was proposed to implement a compact, non-contact optical detection scheme for measuring HbA1c.

Original languageEnglish
Title of host publication18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
PublisherChemical and Biological Microsystems Society
Pages2076-2078
Number of pages3
ISBN (Electronic)9780979806476
Publication statusPublished - 2014 Jan 1
Event18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States
Duration: 2014 Oct 262014 Oct 30

Publication series

Name18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

Other

Other18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
CountryUnited States
CitySan Antonio
Period14-10-2614-10-30

Fingerprint

Medical problems
Monitoring
Hemoglobin
Sensors
Surface plasmon resonance
Microfluidics
Molecules

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering

Cite this

Chang, K. W., Chou, H. T., Yang, C. H., Shiesh, S. C., Lee, M. C., & Lee, G. B. (2014). On-Chip HbA1C detection utlizing a compact surface pla-smon grating sensor integrated on a microfldic system. In 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 (pp. 2076-2078). (18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014). Chemical and Biological Microsystems Society.
Chang, Ko Wei ; Chou, Huan Ting ; Yang, Ching Hsuan ; Shiesh, Shu Chu ; Lee, Ming Chang ; Lee, Gwo Bin. / On-Chip HbA1C detection utlizing a compact surface pla-smon grating sensor integrated on a microfldic system. 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society, 2014. pp. 2076-2078 (18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014).
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abstract = "Diabetes mellitus may cause serious complications, including arteriosclerosis, heart disease and kidney failure, and therefore requires routine monitoring. Increasing evidences show that the concentration of glycated hemoglobin (HbA1c) can be utilized as a more reliable index for diagnosing and monitoring diabetes. In this study, we presented a new approach using HbA1c-specific aptamers as recognition molecules due to its high affinity and specificity. Moreover, a compact, grating-based surface plasmon resonance sensor incorporated with a microfluidic system was proposed to implement a compact, non-contact optical detection scheme for measuring HbA1c.",
author = "Chang, {Ko Wei} and Chou, {Huan Ting} and Yang, {Ching Hsuan} and Shiesh, {Shu Chu} and Lee, {Ming Chang} and Lee, {Gwo Bin}",
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language = "English",
series = "18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014",
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Chang, KW, Chou, HT, Yang, CH, Shiesh, SC, Lee, MC & Lee, GB 2014, On-Chip HbA1C detection utlizing a compact surface pla-smon grating sensor integrated on a microfldic system. in 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, Chemical and Biological Microsystems Society, pp. 2076-2078, 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, San Antonio, United States, 14-10-26.

On-Chip HbA1C detection utlizing a compact surface pla-smon grating sensor integrated on a microfldic system. / Chang, Ko Wei; Chou, Huan Ting; Yang, Ching Hsuan; Shiesh, Shu Chu; Lee, Ming Chang; Lee, Gwo Bin.

18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society, 2014. p. 2076-2078 (18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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N2 - Diabetes mellitus may cause serious complications, including arteriosclerosis, heart disease and kidney failure, and therefore requires routine monitoring. Increasing evidences show that the concentration of glycated hemoglobin (HbA1c) can be utilized as a more reliable index for diagnosing and monitoring diabetes. In this study, we presented a new approach using HbA1c-specific aptamers as recognition molecules due to its high affinity and specificity. Moreover, a compact, grating-based surface plasmon resonance sensor incorporated with a microfluidic system was proposed to implement a compact, non-contact optical detection scheme for measuring HbA1c.

AB - Diabetes mellitus may cause serious complications, including arteriosclerosis, heart disease and kidney failure, and therefore requires routine monitoring. Increasing evidences show that the concentration of glycated hemoglobin (HbA1c) can be utilized as a more reliable index for diagnosing and monitoring diabetes. In this study, we presented a new approach using HbA1c-specific aptamers as recognition molecules due to its high affinity and specificity. Moreover, a compact, grating-based surface plasmon resonance sensor incorporated with a microfluidic system was proposed to implement a compact, non-contact optical detection scheme for measuring HbA1c.

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Chang KW, Chou HT, Yang CH, Shiesh SC, Lee MC, Lee GB. On-Chip HbA1C detection utlizing a compact surface pla-smon grating sensor integrated on a microfldic system. In 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society. 2014. p. 2076-2078. (18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014).