TY - GEN
T1 - On-Chip HbA1C detection utlizing a compact surface pla-smon grating sensor integrated on a microfldic system
AU - Chang, Ko Wei
AU - Chou, Huan Ting
AU - Yang, Ching Hsuan
AU - Shiesh, Shu Chu
AU - Lee, Ming Chang
AU - Lee, Gwo Bin
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Diabetes mellitus may cause serious complications, including arteriosclerosis, heart disease and kidney failure, and therefore requires routine monitoring. Increasing evidences show that the concentration of glycated hemoglobin (HbA1c) can be utilized as a more reliable index for diagnosing and monitoring diabetes. In this study, we presented a new approach using HbA1c-specific aptamers as recognition molecules due to its high affinity and specificity. Moreover, a compact, grating-based surface plasmon resonance sensor incorporated with a microfluidic system was proposed to implement a compact, non-contact optical detection scheme for measuring HbA1c.
AB - Diabetes mellitus may cause serious complications, including arteriosclerosis, heart disease and kidney failure, and therefore requires routine monitoring. Increasing evidences show that the concentration of glycated hemoglobin (HbA1c) can be utilized as a more reliable index for diagnosing and monitoring diabetes. In this study, we presented a new approach using HbA1c-specific aptamers as recognition molecules due to its high affinity and specificity. Moreover, a compact, grating-based surface plasmon resonance sensor incorporated with a microfluidic system was proposed to implement a compact, non-contact optical detection scheme for measuring HbA1c.
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M3 - Conference contribution
AN - SCOPUS:84941654391
T3 - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
SP - 2076
EP - 2078
BT - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
PB - Chemical and Biological Microsystems Society
T2 - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
Y2 - 26 October 2014 through 30 October 2014
ER -
