Abstract
Objective. The goal of this study was to investigate, using model simulations and animal experiments, the efficiency and the side effects of burst high frequency stimulation combined with on-off control in seizure suppression. Approach. A modified mathematical hippocampal seizure model was created to provide evidence of the eligibility of this approach. In the experimental setup, two recording electrodes were inserted into bilateral septal CA1 of the hippocampus, and a stimulation electrode was placed on the ventral hippocampal commissure of a rat. After seizures had been induced by 4-aminopyridine treatment, on-off control stimulation was used to suppress the seizures at 20 s intervals. The stimulation time, cumulative charge and post-stimulation suppression were used to assess the effects of burst duration. Main results. The results showed that burst stimulation could suppress the seizures during the control period and burst stimulation of a shorter duration could keep the seizure suppressed with less effort. By decreasing the burst duration, the cumulative stimulation time became shorter, the delivered cumulative charge became lower, and the cumulative time of post-stimulation suppression became longer. Significance. The on-off control stimulation not only prolonged the duration of suppression but also avoided the side effects of the conversion of seizure patterns. In particular, decreasing the specified burst duration increased the efficiency of the burst stimulation.
| Original language | English |
|---|---|
| Article number | 036017 |
| Journal | Journal of Neural Engineering |
| Volume | 10 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2013 Jun 1 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Biomedical Engineering
- Cellular and Molecular Neuroscience
Cite this
}
On-off control of burst high frequency electrical stimulation to suppress 4-AP induced seizures. / Chiang, Chia Chu; Lin, Chou-Ching; Ju, Ming-Shaung.
In: Journal of Neural Engineering, Vol. 10, No. 3, 036017, 01.06.2013.Research output: Contribution to journal › Article
TY - JOUR
T1 - On-off control of burst high frequency electrical stimulation to suppress 4-AP induced seizures
AU - Chiang, Chia Chu
AU - Lin, Chou-Ching
AU - Ju, Ming-Shaung
PY - 2013/6/1
Y1 - 2013/6/1
N2 - Objective. The goal of this study was to investigate, using model simulations and animal experiments, the efficiency and the side effects of burst high frequency stimulation combined with on-off control in seizure suppression. Approach. A modified mathematical hippocampal seizure model was created to provide evidence of the eligibility of this approach. In the experimental setup, two recording electrodes were inserted into bilateral septal CA1 of the hippocampus, and a stimulation electrode was placed on the ventral hippocampal commissure of a rat. After seizures had been induced by 4-aminopyridine treatment, on-off control stimulation was used to suppress the seizures at 20 s intervals. The stimulation time, cumulative charge and post-stimulation suppression were used to assess the effects of burst duration. Main results. The results showed that burst stimulation could suppress the seizures during the control period and burst stimulation of a shorter duration could keep the seizure suppressed with less effort. By decreasing the burst duration, the cumulative stimulation time became shorter, the delivered cumulative charge became lower, and the cumulative time of post-stimulation suppression became longer. Significance. The on-off control stimulation not only prolonged the duration of suppression but also avoided the side effects of the conversion of seizure patterns. In particular, decreasing the specified burst duration increased the efficiency of the burst stimulation.
AB - Objective. The goal of this study was to investigate, using model simulations and animal experiments, the efficiency and the side effects of burst high frequency stimulation combined with on-off control in seizure suppression. Approach. A modified mathematical hippocampal seizure model was created to provide evidence of the eligibility of this approach. In the experimental setup, two recording electrodes were inserted into bilateral septal CA1 of the hippocampus, and a stimulation electrode was placed on the ventral hippocampal commissure of a rat. After seizures had been induced by 4-aminopyridine treatment, on-off control stimulation was used to suppress the seizures at 20 s intervals. The stimulation time, cumulative charge and post-stimulation suppression were used to assess the effects of burst duration. Main results. The results showed that burst stimulation could suppress the seizures during the control period and burst stimulation of a shorter duration could keep the seizure suppressed with less effort. By decreasing the burst duration, the cumulative stimulation time became shorter, the delivered cumulative charge became lower, and the cumulative time of post-stimulation suppression became longer. Significance. The on-off control stimulation not only prolonged the duration of suppression but also avoided the side effects of the conversion of seizure patterns. In particular, decreasing the specified burst duration increased the efficiency of the burst stimulation.
UR - http://www.scopus.com/inward/record.url?scp=84878330326&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84878330326&partnerID=8YFLogxK
U2 - 10.1088/1741-2560/10/3/036017
DO - 10.1088/1741-2560/10/3/036017
M3 - Article
C2 - 23648994
AN - SCOPUS:84878330326
VL - 10
JO - Journal of Neural Engineering
JF - Journal of Neural Engineering
SN - 1741-2560
IS - 3
M1 - 036017
ER -